LSD: Autoradiographic Study on the Placental Transfer and Tissue Distribution in Mice
Juhana E. Idänpään-heikkilä, Joseph C. Schoolar
Science June 13, 1969 DOI: 10.1126/science.164.3885.1295 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Pregnant subjects (early and late stage pregnancy) |
| Intervention | 14 C-lysergic acid diethylamide administered intravenously |
| Topics | LSD |
| Keywords | Fetus Placenta Distribution mathematics Endocrinology Excretion Lysergic acid Pregnancy Biochemistry |
| Citations | 32 |
| Key findings | Lysergic acid diethylamide rapidly distributes to multiple organs and crosses the placental barrier, with higher transfer in early versus late pregnancy. |
Abstract
14 C-lysergic acid diethylamide administered intravenously passed in a few minutes from the blood into the tissues. In addition to the brain, the adrenals, hypophysis, kidneys, liver, and lungs showed the highest uptake, much higher than the blood concentration. Excretion into the bile started immediately; this was the most important elimination route. In the early stage of pregnancy, 2.5 percent (and in the late stage, 0.5 percent) of the radioactive dose passed the placental barrier into the fetus in 5 minutes. Over 70 percent of this fetal radioactivity was unchanged 14 C-lysergic acid diethylamide.