POTENTIATION OF SUBSTANCE P BY LYSERGIC ACID DIETHYLAMIDE IN VIVO
British Journal of Pharmacology and Chemotherapy 1961 DOI: 10.1111/j.1476-5381.1961.tb01084.x (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Cats |
| Interventions | Lysergic acid diethylamide 2-Bromolysergic acid diethylamide substance P |
| Dose | 10 mug/kg or more |
| Topics | LSD |
| Citations | 10 |
| Key findings | LSD at higher doses enhances the DR IV potential in cats, and at lower doses reveals an enhancement of this potential by substance P, while 2-bromolysergic acid diethylamide blocks these effects. |
Abstract
In doses of 10 mug/kg or more, lysergic acid diethylamide enhanced the fourth potential (DR IV) of the dorsal root potential complex in the cat. Smaller doses of lysergic acid diethylamide did not in themselves alter the DR IV, but revealed an enhancement of the potential by substance P, which by itself had no effect. 2-Bromolysergic acid diethylamide had no action on the dorsal root potentials, but prevented the actions of lysergic acid diethylamide.
Comparable studies
Other experimental studies on LSD, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Neural correlates of the LSD experience revealed by multimodal neuroimaging. Human participants | 2016 | Experimental study | |
| Crystal structure of an LSD-bound human serotonin receptor | 2017 | Experimental study with structural biology and molecular dynamics simulations | |
| Lysergic Acid Diethylamide: Sensitive Neuronal Units in the Midbrain Raphe Midbrain neurons containing serotonin | 1968 | Experimental study | |
| Connectome-harmonic decomposition of human brain activity reveals dynamical repertoire re-organization under LSD. Human brain | 2017 | Experimental study | |
| LSD-Assisted Psychotherapy in Patients with Terminal Cancer Cancer patients | 1973 | Experimental study | n = 60 |