Persistence of lysergic acid diethylamide in the plasma of human subjects
Clinical Pharmacology & Therapeutics September 1, 1964 DOI: 10.1002/cpt196455611 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Pharmacokinetic study Peer reviewed |
|---|---|
| Sample size | 5 |
| Population | Normal human subjects |
| Dose | 2 micrograms per kilogram |
| Duration | 8 hours |
| Topics | LSD |
| Keywords | Human plasma Persistence discontinuity Plasma levels Half-life Pharmacology Endocrinology Pharmacokinetics Chromatography |
| Citations | 118 |
| Key points | The half-life of LSD-25 in human plasma is 175 minutes. |
Abstract
Two micrograms per kilogram of LSD‐25 was administered intravenously to five normal human subjects. The concentration of drug in plasma was determined serially over the subsequent 8 hours. LSD‐25 was found to be present in human plasma in relatively large quantities during the period of peak effect. The half‐life of LSD‐25 in human plasma was calculated to be 175 minutes.