Persistence of lysergic acid diethylamide in the plasma of human subjects
Clinical Pharmacology & Therapeutics September 1, 1964 DOI: 10.1002/cpt196455611 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Pharmacokinetic study Peer reviewed |
|---|---|
| Sample size | 5 |
| Population | Normal human subjects |
| Dose | 2 micrograms per kilogram |
| Duration | 8 hours |
| Topics | LSD |
| Keywords | Human plasma Persistence discontinuity Plasma levels Half-life Pharmacology Endocrinology Pharmacokinetics Chromatography |
| Citations | 118 |
| Key points | The half-life of LSD-25 in human plasma is 175 minutes. |
Abstract
Two micrograms per kilogram of LSD‐25 was administered intravenously to five normal human subjects. The concentration of drug in plasma was determined serially over the subsequent 8 hours. LSD‐25 was found to be present in human plasma in relatively large quantities during the period of peak effect. The half‐life of LSD‐25 in human plasma was calculated to be 175 minutes.
Comparable studies
Other experimental studies on LSD, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Neural correlates of the LSD experience revealed by multimodal neuroimaging. Human participants | 2016 | Experimental study | |
| Crystal structure of an LSD-bound human serotonin receptor | 2017 | Experimental study with structural biology and molecular dynamics simulations | |
| Lysergic Acid Diethylamide: Sensitive Neuronal Units in the Midbrain Raphe Midbrain neurons containing serotonin | 1968 | Experimental study | |
| Connectome-harmonic decomposition of human brain activity reveals dynamical repertoire re-organization under LSD. Human brain | 2017 | Experimental study | |
| LSD-Assisted Psychotherapy in Patients with Terminal Cancer Cancer patients | 1973 | Experimental study | n = 60 |
Citations in the library
Cited by 30
- The Pharmacology of Lysergic Acid Diethylamide: A Review CNS Neuroscience & Therapeutics November 11, 2008
- Dose-Response Study of N,N-Dimethyltryptamine in Humans Archives of General Psychiatry February 1, 1994
- Psychedelics and Immunomodulation: Novel Approaches and Therapeutic Opportunities Frontiers in Immunology July 14, 2015
- 2,5-Dimethoxy-4-methyl-amphetamine (STP): A New Hallucinogenic Drug Science November 3, 1967
- LSD and Genetic Damage Science April 30, 1971
and 25 more in the library