Some Effects of Bufotenine and Lysergic Acid Diethylamide on the Monkey
Archives of Neurology And Psychiatry 1956 DOI: 10.1001/archneurpsyc.1956.02330190065004 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Observational study Peer reviewed |
|---|---|
| Population | Anesthetized dogs |
| Intervention | bufotenine |
| Topics | LSD Mescaline |
| Keywords | Pharmacology Traditional medicine Hallucinogen |
| Citations | 52 |
| Key findings | Bufotenine, isolated from Piptadenia peregrina beans used in cohoba snuff, has been linked to hallucinogenic effects similar to mescaline, harmine, and lysergic acid diethylamide, prompting further study of its effects on unanesthetized animals. |
Abstract
INTRODUCTION Bufotenine (5 -hydroxy -3 -[2- dimethyl-aminoethyl]-indole) is the N-dimethyl derivative of the vasoconstrictor substance serotonin (5-hydroxytryptamine). It was first synthesized by Wieland in 1934. Raymond-Hamet found that intravenous injection of bufotenine caused transient elevation of blood pressure and apnea, followed by tachypnea, in anesthetized dogs.* To date, however, there is little published material concerning the effects of bufotenine on unanesthetized animals. Our interest in such effects was based on the fact that bufotenine was recently isolated from the bean of Piptadenia peregrina,5a bean long known to be the source of cohoba, a narcotic snuff. This snuff has been used by inhabitants of the West Indies to induce hallucinations and mystical states,6states which seem similar to those produced by mescaline, harmine, and lysergic acid diethylamide. It was felt, in view of the reported psychological effects of bufotenine-containing snuff, that it would be worth while to investigate
Comparable studies
Other observational and cohort studies on LSD, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Increased Global Functional Connectivity Correlates with LSD-Induced Ego Dissolution. Human participants | 2016 | Observational cohort | |
| Increased spontaneous MEG signal diversity for psychoactive doses of ketamine, LSD and psilocybin Humans | 2017 | Observational study | |
| Classic psychedelic use is associated with reduced psychological distress and suicidality in the United States adult population. USA adult respondents from the National Survey on Drug Use and Health (2008-2012) | 2015 | Observational cohort | n = 190,000 |
| Psychedelics not linked to mental health problems or suicidal behavior: A population study Randomly selected United States adults | 2015 | Observational cohort | n = 135,095 |
| Whole-Brain Multimodal Neuroimaging Model Using Serotonin Receptor Maps Explains Non-linear Functional Effects of LSD. Healthy human participants | 2018 | Observational study with computational modeling |
Citations in the library
Cited by 9
- The Pharmacology of Lysergic Acid Diethylamide: A Review CNS Neuroscience & Therapeutics November 11, 2008
- Bufo toads and bufotenine: fact and fiction surrounding an alleged psychedelic. Journal of Psychoactive Drugs 1996
- An Animal Behavior Model for Studying the Actions of LSD and Related Hallucinogens Science November 12, 1976
- Opposite effects of intraventricular serotonin and bufotenin on rat startle responses. Pharmacology, Biochemistry, and Behavior 1975
- Intoxication of dogs and cats with common stimulating, hallucinogenic and dissociative recreational drugs. Veterinary and animal science March 1, 2023
and 4 more in the library