Opposite effects of intraventricular serotonin and bufotenin on rat startle responses.
Mark A. Geyer, J D Warbritton, D B Menkes, John A. Zook, Arnold J. Mandell
Pharmacology, Biochemistry, and Behavior 1975 DOI: 10.1016/0091-3057(75)90193-8 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Rats |
| Interventions | 5-hydroxytrptamine (5-HT) 5-hydroxy-N saline |
| Topics | Serotonin |
| Citations | 34 |
| Key findings | Serotonin decreased startle responses dose-dependently, while the hallucinogen 5-HDMT increased startle magnitude, with no specific effects on sensitization or habituation. |
Abstract
Rat startle responses to air puffs were monitored in a stabilimeter during the intraventricular infusion of various doses of 5-hydroxytrptamine (5-HT) or the putative hallucinogenic congener of 5-HT, 5-hydroxy-N, N-dimethyltrytamine (5-HDMT) or saline. Qualitativity opposite effects were observed, with 5-HT producing a dose-dependent decrease in responsivity and 5-HDMT increasing the magnitude of startle responses. No specific effects of either compound could be demonstrated on the presumably separable processes of sensitization and habituation. The results are discussed in the context of a central serotonergic system which facilitates behavioral inhibition and which is antagonized by indoleamine hallucinogens.
Comparable studies
Other preclinical and animal studies on serotonin, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Psilocybin induces rapid and persistent growth of dendritic spines in frontal cortex in vivo Mice | 2021 | Observational cohort | |
| Neurotoxicity of the psychedelic amphetamine, methylenedioxymethamphetamine. Rats (implied by typical neurochemical study context) | 1987 | Experimental study | |
| Psychedelics promote neuroplasticity through the activation of intracellular 5-HT2A receptors In vitro and in vivo (rodent) models | 2023 | Experimental study | |
| 3,4-Methylenedioxymethamphetamine and 3,4-methylenedioxyamphetamine destroy serotonin terminals in rat brain: quantification of neurodegeneration by measurement of [3H]paroxetine-labeled serotonin uptake sites. Rat brain | 1987 | Animal experiment | |
| Comparison of the monoamine transporters from human and mouse in their sensitivities to psychostimulant drugs Human and mouse dopamine, norepinephrine, and serotonin transporters expressed in cells | 2006 | In vitro laboratory study |
Citations in the library
Cited by 6
- Bufo toads and bufotenine: fact and fiction surrounding an alleged psychedelic. Journal of Psychoactive Drugs 1996
- Bufotenine: toward an understanding of possible psychoactive mechanisms. Journal of Psychoactive Drugs 2000
- 5-Methoxy-N,N-dimethyltryptamine: spinal cord and brainstem mediation of excitatory effects on acoustic startle. Psychopharmacology 1980
- Psilocybin: Biphasic dose-response effects on the acoustic startle reflex in the rat Pharmacology, Biochemistry, and Behavior April 1, 1977
- Mescaline increases startle responding equally in normal and raphe-lesioned rats Pharmacology, Biochemistry, and Behavior February 1, 1979
and 1 more in the library