6-Hydroxydopamine inhibits some effects of mescaline centrally administered to rabbits
Sergio Solbes Ferri, Roser Reina, C. Spadaro, P. C. Braga
Psychopharmacology June 1, 1977 DOI: 10.1007/bf01457850 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Rabbits |
| Interventions | Mescaline Naloxone 6-hydroxydopamine |
| Dose | 100 microgram/kg of mescaline |
| Topics | Mescaline |
| Keywords | Hydroxydopamine Pharmacology +-naloxone Antagonist Hallucinogen Morphine Dopaminergic Receptor |
| Citations | 3 |
| Key findings | 6-hydroxydopamine, but not naloxone, prevents mescaline-induced antinociception and stereotyped behavior in rabbits, suggesting a crucial role for catecholamines. |
Abstract
The narcotic antagonist naloxone does not antagonize antinociception elicited in the rabbit by 100 microgram/kg of mescaline centrally administered, whereas pretreatment with 6-hydroxydopamine (6-OHDA) inhibits this mescaline effect. Stereotyped behavior of rabbits following central mescaline administration is also prevented by 6-hda pretreatment. Since 6-OHDA in known to produce a degeneration of catecholamine containing nerve terminals, a crucial role of catecholamines is suggested in the complex of effects seen in the rabbit after central administration of the hallucinogen.