6-Hydroxydopamine inhibits some effects of mescaline centrally administered to rabbits
Sergio Solbes Ferri, Roser Reina, C. Spadaro, P. C. Braga
Psychopharmacology June 1, 1977 DOI: 10.1007/bf01457850 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Rabbits |
| Interventions | Mescaline Naloxone 6-hydroxydopamine |
| Dose | 100 microgram/kg of mescaline |
| Topics | Mescaline |
| Keywords | Hydroxydopamine Pharmacology +-naloxone Antagonist Hallucinogen Morphine Dopaminergic Receptor |
| Citations | 3 |
| Key findings | 6-hydroxydopamine, but not naloxone, prevents mescaline-induced antinociception and stereotyped behavior in rabbits, suggesting a crucial role for catecholamines. |
Abstract
The narcotic antagonist naloxone does not antagonize antinociception elicited in the rabbit by 100 microgram/kg of mescaline centrally administered, whereas pretreatment with 6-hydroxydopamine (6-OHDA) inhibits this mescaline effect. Stereotyped behavior of rabbits following central mescaline administration is also prevented by 6-hda pretreatment. Since 6-OHDA in known to produce a degeneration of catecholamine containing nerve terminals, a crucial role of catecholamines is suggested in the complex of effects seen in the rabbit after central administration of the hallucinogen.
Comparable studies
Other experimental studies on mescaline, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Enzymatic Formation of Psychotomimetic Metabolites from Normally Occurring Compounds Rabbit lung | 1961 | Experimental study | |
| PSYCHOTOMIMETICS, CLINICAL AND THEORETICAL CONSIDERATIONS: HARMINE, WIN-2299 AND NALLINE Schizophrenic patients | 1957 | Experimental study | |
| Phencyclidine, Lysergic Acid Diethylamide, and Mescaline: Cerebral Artery Spasms and Hallucinogenic Activity Isolated basilar and middle cerebral arteries | 1981 | Experimental study | |
| Acquired and Crossed Tolerance to Mescaline, LSD-25, and BOL-148 | 1959 | Experimental study | |
| Effects of Hallucinogenic and Tranquilizing Drugs on Serotonin Evoked Uterine Contractions. Uterus of spayed rat | 1956 | Experimental study |
Citations in the library
Cites 2
- Development of tolerance to the antinociceptive effect of mescaline intraventricularly administered to rabbits Psychopharmacology 1976
- Cross tolerance to antinociception elicited by intracerebroventricular administration of mescaline and morphine to rabbits, and EEG correlates Psychopharmacology 1976