Cross tolerance to antinociception elicited by intracerebroventricular administration of mescaline and morphine to rabbits, and EEG correlates
Sergio Solbes Ferri, A. Santagostino, Pier Carlo Braga
Psychopharmacology 1976 DOI: 10.1007/bf00427611 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Rabbits |
| Interventions | morphine mescaline |
| Dose | 10 mug/kg morphine, 100 mug/kg mescaline |
| Topics | Mescaline |
| Keywords | Morphine Nociception Cross-tolerance Pharmacology Electroencephalography Drug tolerance Anesthesia |
| Citations | 4 |
| Key findings | Tolerance and cross-tolerance to the antinociceptive effect of equipotent doses of morphine and mescaline occur after repeated intracerebroventricular administration in rabbits, and partial tolerance develops to the EEG effects of mescaline. |
Abstract
Tolerance and cross tolerance to the antinociceptive effect of equipotent doses of morphine (10 mug/kg) and mescaline (100 mug/kg) are shown in the rabbit after their repeated intracerebroventricular administration. The recording of the electrical activity of different brain areas indicates that a partial tolerance also develops to the EEG effects in animals undergoing chronic treatment with mescaline. The comparison of certain of the mescaline-induced effects with those of morphine suggests that some biochemical and neural patterns are common to the 2 drugs.
Comparable studies
Other experimental studies on mescaline, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Enzymatic Formation of Psychotomimetic Metabolites from Normally Occurring Compounds Rabbit lung | 1961 | Experimental study | |
| PSYCHOTOMIMETICS, CLINICAL AND THEORETICAL CONSIDERATIONS: HARMINE, WIN-2299 AND NALLINE Schizophrenic patients | 1957 | Experimental study | |
| Phencyclidine, Lysergic Acid Diethylamide, and Mescaline: Cerebral Artery Spasms and Hallucinogenic Activity Isolated basilar and middle cerebral arteries | 1981 | Experimental study | |
| Acquired and Crossed Tolerance to Mescaline, LSD-25, and BOL-148 | 1959 | Experimental study | |
| Effects of Hallucinogenic and Tranquilizing Drugs on Serotonin Evoked Uterine Contractions. Uterus of spayed rat | 1956 | Experimental study |
Citations in the library
Cited by 2
- Novel, Unifying Mechanism for Mescaline in The Central Nervous System: Electrochemistry, Catechol Redox Metabolite, Receptor, Cell Signaling and Structure Activity Relationships Oxidative Medicine and Cellular Longevity 2009
- 6-Hydroxydopamine inhibits some effects of mescaline centrally administered to rabbits Psychopharmacology June 1, 1977