Development of tolerance to the antinociceptive effect of mescaline intraventricularly administered to rabbits
Sergio Solbes Ferri, A. Santagostino, P. C. Braga
Psychopharmacology 1976 DOI: 10.1007/bf00427610 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Conscious rabbits |
| Intervention | Mescaline |
| Dose | 70, 100, 150 mug/kg |
| Duration | Acute treatment and daily administration for 5 days |
| Topics | Mescaline |
| Keywords | Nociception Morphine Pharmacology Stimulation Anesthesia |
| Citations | 6 |
| Key findings | Acute intraventricular mescaline produces dose-dependent analgesia in rabbits, but complete tolerance develops to this effect with repeated daily administration. |
Abstract
Some effects of intraventricular injection of mescaline are examined in conscious rabbits. By means of electrical stimulation of the tooth pulp it is shown that an acute treatment with 70, 100, 150 mug/kg of mescaline elicits analgesia, the intensity of which is dose-dependent: with daily administration of 100 mug/kg for 5 days a complete tolerance develops to the antinociceptive effect. A tolerance also develops to the behavioral effects of mescaline after repeated administrations, with the exception of the stuporous state, a symptom which, on the contrary, is accentuated as the treatment proceeds. An EEG arousal is induced in the rabbit by acutely administered mescaline; the chronic treatment (100 mug/kg) makes the return of voltage to original levels progressively slower. Finally, the confrontation of certain of the mescaline-induced effects with those of morphine suggests some biochemical and neural patterns common to the 2 drugs.