Development of tolerance to the antinociceptive effect of mescaline intraventricularly administered to rabbits
Sergio Solbes Ferri, A. Santagostino, P. C. Braga
Psychopharmacology 1976 DOI: 10.1007/bf00427610 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Conscious rabbits |
| Intervention | Mescaline |
| Dose | 70, 100, 150 mug/kg |
| Duration | Acute treatment and daily administration for 5 days |
| Topics | Mescaline |
| Keywords | Nociception Morphine Pharmacology Stimulation Anesthesia |
| Citations | 6 |
| Key findings | Acute intraventricular mescaline produces dose-dependent analgesia in rabbits, but complete tolerance develops to this effect with repeated daily administration. |
Abstract
Some effects of intraventricular injection of mescaline are examined in conscious rabbits. By means of electrical stimulation of the tooth pulp it is shown that an acute treatment with 70, 100, 150 mug/kg of mescaline elicits analgesia, the intensity of which is dose-dependent: with daily administration of 100 mug/kg for 5 days a complete tolerance develops to the antinociceptive effect. A tolerance also develops to the behavioral effects of mescaline after repeated administrations, with the exception of the stuporous state, a symptom which, on the contrary, is accentuated as the treatment proceeds. An EEG arousal is induced in the rabbit by acutely administered mescaline; the chronic treatment (100 mug/kg) makes the return of voltage to original levels progressively slower. Finally, the confrontation of certain of the mescaline-induced effects with those of morphine suggests some biochemical and neural patterns common to the 2 drugs.
Comparable studies
Other experimental studies on mescaline, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Enzymatic Formation of Psychotomimetic Metabolites from Normally Occurring Compounds Rabbit lung | 1961 | Experimental study | |
| PSYCHOTOMIMETICS, CLINICAL AND THEORETICAL CONSIDERATIONS: HARMINE, WIN-2299 AND NALLINE Schizophrenic patients | 1957 | Experimental study | |
| Phencyclidine, Lysergic Acid Diethylamide, and Mescaline: Cerebral Artery Spasms and Hallucinogenic Activity Isolated basilar and middle cerebral arteries | 1981 | Experimental study | |
| Acquired and Crossed Tolerance to Mescaline, LSD-25, and BOL-148 | 1959 | Experimental study | |
| Effects of Hallucinogenic and Tranquilizing Drugs on Serotonin Evoked Uterine Contractions. Uterus of spayed rat | 1956 | Experimental study |
Citations in the library
Cited by 3
- Novel, Unifying Mechanism for Mescaline in The Central Nervous System: Electrochemistry, Catechol Redox Metabolite, Receptor, Cell Signaling and Structure Activity Relationships Oxidative Medicine and Cellular Longevity 2009
- Cross tolerance to antinociception elicited by intracerebroventricular administration of mescaline and morphine to rabbits, and EEG correlates Psychopharmacology 1976
- 6-Hydroxydopamine inhibits some effects of mescaline centrally administered to rabbits Psychopharmacology June 1, 1977
Cites 3
- Some Effects of Bufotenine and Lysergic Acid Diethylamide on the Monkey Archives of Neurology And Psychiatry 1956
- Behavioral and Electroencephalographic Effects of Hallucinogenic Drugs A M A Archives of Neurology & Psychiatry 1956
- Effects of Mescaline in Laboratory Animals and Influence of Ataraxics on Mescaline-Response Experimental Biology and Medicine June 1, 1956