Naloxone potentiates the disruptive effects of mescaline on operant responding in the rat
Randall L. Commissaris, K.E. Moore, Richard H. Rech
Pharmacology, Biochemistry, and Behavior October 1, 1980 DOI: 10.1016/0091-3057(80)90289-0 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Food-deprived male rats |
| Interventions | Mescaline Naloxone |
| Dose | 4.0--10.0 mg/kg mescaline; 1.0-8.0 mg/kg naloxone |
| Duration | 40-minute operant session |
| Topics | Mescaline |
| Keywords | +-naloxone Pharmacology Antagonist Reinforcement Self-administration Hallucinogen Anesthesia Receptor |
| Citations | 8 |
| Key findings | Pretreatment with naloxone dose-dependently potentiated the disruptive effects of mescaline on operant responding in rats. |
Abstract
Food-deprived male rats were trained to press a lever on a fixed ratio-40 (FR-40) operant schedule for food reinforcement. Administration of mescaline (4.0--10.0 mg/kg) immediately before the start of the operant session resulted in a cessation of responding for some portion of the 40-min period ("hallucinatory pause"). The duration of this pause was found to be dose-dependent. Although administration of naloxone alone (1.0-8.0 mg/kg, five minutes prior to the start of the session) had no effect on FR-40 responding per se, pretreatment with this agent significantly potentiated the disruptive effects of mescaline. This potentiation by naloxone was further shown to be dose-dependent. These data suggest that the effects of the phenethylamine hallucinogen mescaline are potentiated by pretreatment with the narcotic antagonist naloxone.
Comparable studies
Other preclinical and animal studies on mescaline, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Correlation between the potency of hallucinogens in the mouse head-twitch response assay and their behavioral and subjective effects in other species. C57BL/6J mice | 2020 | Experimental study with dose-response experiments | |
| Brain mechanisms of hallucinogens and entactogens Humans and rats | 2001 | Review | |
| Effects of hallucinogenic agents mescaline and phencyclidine on zebrafish behavior and physiology Zebrafish (Danio rerio) | 2012 | Experimental study | |
| Lysergic Acid Diethylamide- and Mescaline-Induced Attenuation of the Effect of Punishment in the Rat Rats | 1976 | Experimental study | |
| Dihydrobenzofuran Analogues of Hallucinogens. 3. Models of 4-Substituted (2,5-Dimethoxyphenyl)alkylamine Derivatives with Rigidified Methoxy Groups Rats (trained to discriminate saline from LSD tartrate) and rat cortical and... | 1996 | In vivo drug discrimination assay and in vitro radioligand binding assay |
Citations in the library
Cited by 3
- The 5HT2 antagonist pirenperone reverses disruption of FR-40 by hallucinogenic drugs. Pharmacology, Biochemistry, and Behavior May 1985
- Naloxone alters the effects of LSD, DOM and quipazine on operant behavior of rats. Pharmacology, Biochemistry, and Behavior September 1984
- Effects of selected opioid agonists and antagonists on DMT- and LSD-25-induced disruption of food-rewarded bar pressing behavior in the rat. Psychopharmacology 1981
Cites 5
- Generalization of morphine and lysergic acid diethylamide (LSD) stimulus properties to narcotic analgesics Psychopharmacology 1976
- Behavioral sensitivity to LSD: Dependency upon the pattern of central 5HT depletion Pharmacology, Biochemistry, and Behavior May 1, 1977
- Interaction between narcotic antagonist (naloxone) and lysergic acid diethylamide (LSD) in the rat Psychopharmacology 1977
- Pharmacological and behavioral components of tolerance to LSD and mescaline in rats Pharmacology, Biochemistry, and Behavior September 1, 1977
- Naloxone enhancement of DMT and LSD-25 induced suppression of food-rewarded bar pressing behavior in the rat. Psychopharmacology April 25, 1979