Bioassay of Ataractics Against Lethal Action of Mescaline in Mice
Nicholas P. Plotnikoff, Helen Washington
Experimental Biology and Medicine July 1, 1958 DOI: 10.3181/00379727-98-24143 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | CF1 mice |
| Interventions | chlorpromazine perphenazine proclorperazine promazine thiopropazate promethazine reserpine sodium phenobarbital meprobamate benactyzine atropine hydroxyzine ethoxybutamoxane SY-21 diphenylhydantoin trimethadione lysergic acid diethylamide serotonin amphetamine morphine pyrilamine diphenhydramine iproniazid pilocarpine arecoline |
| Topics | Mescaline |
| Keywords | Promethazine Pharmacology Chlorpromazine Perphenazine Atropine Hydroxyzine Diphenhydramine Iproniazid Pyrilamine Reserpine Meprobamate Chlordiazepoxide Diazepam Plant-based medicinal research |
| Citations | 7 |
| Key findings | Chlorpromazine, perphenazine, proclorperazine, promazine, thiopropazate, promethazine, and reserpine are effective antagonists of mescaline-induced mortality in CF1 mice. |
Abstract
1. It has been demonstrated that chlorpromazine, perphenazine, proclorperazine, promazine, thiopropazate, promethazine and reserpine are effective antagonists of mescaline-induced mortality in CF1 mice. 2. No significant protection was found with use of sodium phenobarbital, meprobamate, benactyzine, atropine, hydroxyzine, ethoxybutamoxane, SY-21, diphenylhydantoin, trimethadione, lysergic acid diethylamide, serotonin, amphetamine, morphine, pyrilamine, diphenhydramine, iproniazid, pilocarpine, and arecoline. 3. It is suggested that the protective effects of the ataractics against mescalineinduced mortality are centrally mediated.
Comparable studies
Other preclinical and animal studies on mescaline, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Correlation between the potency of hallucinogens in the mouse head-twitch response assay and their behavioral and subjective effects in other species. C57BL/6J mice | 2020 | Experimental study with dose-response experiments | |
| Brain mechanisms of hallucinogens and entactogens Humans and rats | 2001 | Review | |
| Effects of hallucinogenic agents mescaline and phencyclidine on zebrafish behavior and physiology Zebrafish (Danio rerio) | 2012 | Experimental study | |
| Lysergic Acid Diethylamide- and Mescaline-Induced Attenuation of the Effect of Punishment in the Rat Rats | 1976 | Experimental study | |
| Dihydrobenzofuran Analogues of Hallucinogens. 3. Models of 4-Substituted (2,5-Dimethoxyphenyl)alkylamine Derivatives with Rigidified Methoxy Groups Rats (trained to discriminate saline from LSD tartrate) and rat cortical and... | 1996 | In vivo drug discrimination assay and in vitro radioligand binding assay |