THE NATURE OF THE BINDING BETWEEN LSD AND A 5‐HT RECEPTOR: A POSSIBLE EXPLANATION FOR HALLUCINOGENIC ACTIVITY
M J Berridge, William D. Prince
British Journal of Pharmacology June 1, 1974 DOI: 10.1111/j.1476-5381.1974.tb09657.x (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Isolated salivary glands of Calliphora (blowfly) |
| Interventions | LSD tryptamine gramine |
| Topics | LSD Serotonin |
| Keywords | Tryptamine Agonist Hallucinogen Endocrinology 5-HT Receptor Pharmacology |
| Citations | 26 |
| Key findings | LSD acts as a slow-dissociating agonist at serotonin receptors in blowfly salivary glands, which may underlie its potent central nervous system effects. |
Abstract
(+)‐Lysergic acid diethylamide (LSD) mimicked 5‐hydroxytryptamine (5‐HT) in its ability to stimulate fluid secretion, to change transepithelial and intracellular potentials as well as to increase the cyclic 3′,5′‐adenosine monophosphate (cyclic AMP) concentrations of isolated salivary glands of Calliphora . Unlike 5‐HT, LSD disengages slowly from the receptor and fluid secretion continues despite repeated washing. Both 5‐HT and tryptamine prevented LSD from acting on the glands. LSD bound to the receptor was slowly displaced when glands were treated with agonists (tryptamine) or antagonists (gramine). The property of LSD which permits it to function as an agonist despite remaining tightly bound to the receptor is discussed as a possible basis for its profound effects within the central nervous system.
Comparable studies
Other experimental studies on LSD, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Neural correlates of the LSD experience revealed by multimodal neuroimaging. Human participants | 2016 | Experimental study | |
| Crystal structure of an LSD-bound human serotonin receptor | 2017 | Experimental study with structural biology and molecular dynamics simulations | |
| Lysergic Acid Diethylamide: Sensitive Neuronal Units in the Midbrain Raphe Midbrain neurons containing serotonin | 1968 | Experimental study | |
| Connectome-harmonic decomposition of human brain activity reveals dynamical repertoire re-organization under LSD. Human brain | 2017 | Experimental study | |
| LSD-Assisted Psychotherapy in Patients with Terminal Cancer Cancer patients | 1973 | Experimental study | n = 60 |
Citations in the library
Cited by 3
- N, N-Dimethyltryptamine (DMT), an Endogenous Hallucinogen: Past, Present, and Future Research to Determine Its Role and Function Frontiers in Neuroscience August 6, 2018
- Serotonergic and dopaminergic distinctions in the behavioral pharmacology of (±)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD) Pharmacology, Biochemistry, and Behavior December 15, 2011
- Phospholipase C mediates (±)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI)-, but not lysergic acid diethylamide (LSD)-elicited head bobs in rabbit medial prefrontal cortex. Brain Research November 1, 2012
Cites 2
- Antagonism of 5‐hydroxytryptamine by LSD 25 in the central nervous system: a possible neuronal basis for the actions of LSD 25 British Journal of Pharmacology October 1, 1970
- Steric and Electronic Relationships among Some Hallucinogenic Compounds Proceedings of the National Academy of Sciences September 1, 1970