Extreme Hyperthermia After LSD Ingestion
JAMA September 13, 1971 DOI: 10.1001/jama.1971.03190110067020 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Case study Case report Peer reviewed |
|---|---|
| Sample size | 1 |
| Population | A human patient who ingested LSD |
| Intervention | alcoholic-ice soaks |
| Topics | LSD |
| Keywords | Hyperthermia Ingestion Anesthesia Restraint-related deaths |
| Citations | 37 |
| Key findings | Life-threatening hyperthermia following LSD use can be rapidly reversed with alcoholic-ice soaks, and the patient recovered without obvious injury. |
Abstract
Hyperthermia is a known effect of lysergic acid diethylamide (LSD). This is, to our knowledge, the first recorded instance of life-threatening hyperthermia (106.4 F [41.3 C] axillary) in man, following the use of LSD, and may have been dose-related. The hyperthermia was rapidly reversed by alcoholic-ice soaks, hallucinations ended about 18 hours later, and the patient recovered without obvious mental or physical injury.
Comparable studies
Other case reports and case series on LSD, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Lasting Neuropsychiatric Sequelae of (??)Methylenedioxymethamphetamine (???Ecstasy???) in Recreational Users Persons who ingested large doses of MDMA | 1991 | Case study | n = 2 |
| Further Studies in the Therapeutic Value of Lysergic Acid Diethylamide in Mental Illness Patients with mental illness | 1957 | Case series | |
| Coma, Hyperthermia, and Bleeding Associated with Massive LSD Overdose a Report of Eight Cases People who self-administered large amounts of pure LSD powder intranasally | 1975 | Case series | n = 8 |
| Using a MDMA- and LSD-Group Therapy Model in Clinical Practice in Switzerland and Highlighting the Treatment of Trauma-Related Disorders Patients with chronic complex post-traumatic stress disorder (c-PTSD), dissociative,... | 2022 | Case series | |
| Persistent Palinopsia Following Ingestion of Lysergic Acid Diethylamide (LSD) Patients who developed persistent palinopsia after LSD ingestion | 1996 | Case series | n = 3 |
Citations in the library
Cited by 6
- Pivotal mental states Journal of Psychopharmacology April 1, 2021
- Serotonin toxicity of serotonergic psychedelics Psychopharmacology July 12, 2021
- Coma, Hyperthermia, and Bleeding Associated with Massive LSD Overdose a Report of Eight Cases Clinical Toxicology 1975
- Acute and long-term effects of psilocybin on energy balance and feeding behavior in mice Translational Psychiatry August 11, 2022
- Pharmacologic Activity of Substituted Tryptamines at 5-Hydroxytryptamine (5-HT)2A Receptor (5-HT2AR), 5-HT2CR, 5-HT1AR, and Serotonin Transporter. Journal of Pharmacology and Experimental Therapeutics January 20, 2023
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