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Behavioral thermoregulation in rats during hyperthermia induced by lysergic acid diethylamide

Naotoshi Murakami, Yoshihiro Sakai, Shigeki Ooki

Neuroscience Letters 1980 DOI: 10.1016/0304-3940(80)90242-6 (opens in new tab)

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Study at a glance

AI-extracted from the abstract
Characteristics Experimental study Peer reviewed
Population Free moving rats
Intervention LSD
Dose 8-16 micrograms
Topics LSD
Citations 9
Key findings LSD-induced hyperthermia is mediated through action on effector pathways, not by an upward setting of the thermostat.

Abstract

In free moving rats trained to press a bar to escape from radiant heat, lysergic acid diethylamide (LSD, 8-16 micrograms) produced a significant and dose-dependent increase of the bar-pressing rate when injected intraperitoneally. During the increase in the bar-pressing rate, the rectal temperature showed an increase and both the tail-skin and the ambient temperature selected decreased concomitantly. The results indicate that LSD-induced hyperthermia is not due to an upward setting of the thermostat but mediated through the action of LSD on the effector pathways in the rats.

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