MDMA induced hyperthermia: a survivor with an initial body temperature of 42.9 degrees C.
Emergency Medicine Journal September 1, 1997 DOI: 10.1136/emj.14.5.336 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Case study Case report Peer reviewed |
|---|---|
| Sample size | 1 |
| Population | Young male who ingested MDMA |
| Interventions | assisted ventilation aggressive fluid therapy dantrolene cooling measures |
| Topics | MDMA |
| Keywords | Rhabdomyolysis Dantrolene Anesthesia Ingestion Metabolic acidosis Malignant hyperthermia Restraint-related deaths |
| Citations | 59 |
| Key findings | A young male survived severe hyperpyrexia (42.9 °C) after MDMA ingestion with treatment including dantrolene, aggressive fluids, and assisted ventilation. |
Abstract
A young male survived hyperpyrexia (42.9 degrees C) following MDMA ("Ecstasy") ingestion. He developed convulsions, rhabdomyolysis, metabolic acidosis, and respiratory failure. This was successfully managed by assisted ventilation, aggressive fluid therapy, and the early administration of dantrolene, in addition to cooling measures. This is the first report of a survivor with such a severe hyperpyrexia.
Comparable studies
Other case reports and case series on MDMA, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| 'Eve' and 'Ecstasy'. A report of five deaths associated with the use of MDEA and MDMA Individuals whose deaths were associated with MDMA or MDEA use | 1987 | Case series | n = 5 |
| Pathology of deaths associated with "ecstasy" and "eve" misuse. Young white men aged 20 to 25 who died after using ring-substituted amphetamines (MDMA... | 1996 | Case series | n = 7 |
| 'Eve' and 'Ecstasy' Individuals who died after using MDMA or MDEA | 1987 | Case series | n = 5 |
| A Method of Conducting Therapeutic Sessions with MDMA Clients with clear therapeutic purpose, excluding those with serious functional... | 1998 | Case study | n = 2 |
| Diversity of Psychopathology Associated with use of 3,4-Methylenedioxymethamphetamine (‘Ecstasy’) Psychiatric patients presenting between 1990 and 1992 whose symptoms developed in the... | 1994 | Case series | n = 13 |
Citations in the library
Cited by 20
- The pharmacology of the acute hyperthermic response that follows administration of 3,4‐methylenedioxymethamphetamine (MDMA, ‘ecstasy’) to rats British Journal of Pharmacology 2002
- A Comprehensive Review of MDMA and GHB: Two Common Club Drugs Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy December 1, 2001
- Multiple MDMA (Ecstasy) Overdoses at a Rave Event Journal of Intensive Care Medicine May 28, 2012
- Attenuation of 3,4‐methylenedioxymethamphetamine (MDMA, Ecstasy)‐induced rhabdomyolysis with α1‐ plus β3‐adrenoreceptor antagonists British Journal of Pharmacology June 1, 2004
- Time-Dependent Molecular Changes Following MDMA-Induced Nephrotoxicity. Iranian journal of pharmaceutical research : IJPR 2024
and 15 more in the library
Cites 3
- Increasing Use of “Ecstasy“ (MDMA) and other Hallucinogens on a College Campus Journal of American College Health May 1, 1994
- Hyperthermia associated with 3,4‐methylenedioxyethamphetamine (‘Eve’) Anaesthesia June 1, 1993
- Toxicity and deaths from 3,4-methylenedioxymethamphetamine ("ecstasy"). The Lancet August 15, 1992