Pharmacologic Activity of Substituted Tryptamines at 5-Hydroxytryptamine (5-HT)2A Receptor (5-HT2AR), 5-HT2CR, 5-HT1AR, and Serotonin Transporter.
Laura B. Kozell, Amy J. Eshleman, Tracy L. Swanson, Shelley H. Bloom, Katherine M. Wolfrum, Jennifer L. Schmachtenberg, Randall J. Olson, Aaron Janowsky, Atheir I. Abbas
J Pharmacol Exp Ther January 20, 2023 DOI: 10.1124/jpet.122.001454 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | In vitro assay Peer reviewed |
|---|---|
| Intervention | substituted tryptamines |
| Topics | Serotonin |
| Keywords | Drug design Medicinal chemistry Therapeutics Neuropharmacology: psychopharmacology Cns research Neurobiology Brain chemistry Serotonergic system Receptor binding Tryptamines: indoleamines Serotonin analogs |
| Citations | 40 |
| Key points | 5-methoxy-substituted tryptamines, particularly 5-MeO-DMT and 5-MeO-tryptamine, are potent agonists at 5-HT2AR and 5-HT2CR, with weak activity at 5-HT1AR and the serotonin transporter. |
Abstract
Pharmacologic Activity of Substituted Tryptamines at 5-Hydroxytryptamine (5-HT)2A Receptor (5-HT2AR), 5-HT2CR, 5-HT1AR, and Serotonin Transporter.