The Experience of Women With Breast or Gynecological Cancer After Participation in an Online Mindfulness-Based Cancer Recovery (e-MBCR) Program: Secondary Outcomes Analysis of a Pilot Mixed Methods Randomized Controlled Trial.
Marie-Estelle Gaignard, Dominica Martin, Jelena Stanic, Roger Hilfiker, Alexandre Bodmer, Michael Ljuslin, Khalil Zaman, Intidhar Labidi-Galy, Apostolos Sarivalasis, Linda E. Carlson, Solange Peters, Pierre-Yves Dietrich, Manuela Eicher, Guido Bondolfi, Françoise Jermann
Psycho-Oncology November 1, 2025 DOI: 10.1002/pon.70334 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Pilot randomized controlled trial with mixed methods Qualitative Peer reviewed |
|---|---|
| Sample size | 62 |
| Population | Women with breast or gynecological cancer |
| Intervention | Online Mindfulness-Based Cancer Recovery (e-MBCR) program |
| Duration | Post-intervention assessment and 3-month follow-up |
| Topics | Depression Meditation |
| Keywords | Mindfulness program Digital mindfulness-based recovery Online mindfulness support Cancer support Breast cancer Gynecological cancer Cancer memories Mental health Well-being Coping skills Self-exploration Self-efficacy Inner work Digital health Online program Digital recovery Online support |
| Registration | NCT04564768 |
| Key findings | The online Mindfulness-Based Cancer Recovery program led to a significant reduction in depression with a medium effect size post-intervention, and qualitative data showed beneficial self-exploration and enhanced self-efficacy, though cancer memories were challenging for some. |
Abstract
Mindfulness-Based Interventions (MBIs) are recognized as beneficial in oncology supportive care. While qualitative analyses of mindfulness program experiences exist, this is the first mixed methods study to examine patients' experiences after participating in the online Mindfulness-Based Cancer Recovery (e-MBCR) program. The SERENITY study was a pilot randomized controlled trial evaluating the early implementation, and effects of the e-MBCR program for women with breast or gynecological cancer in a French-speaking context. This article reports on secondary outcomes from a mixed methods analysis, exploring psychosocial aspects through questionnaires and participants' experiences through interviews. Sixty-two patients were randomized in a 2:1 ratio. Quantitative assessments were carried out at three timepoints; qualitative interviews only post-intervention. Both datasets were analyzed separately, then merged for interpretation. The intervention group showed a significant reduction in depression compared to the control group, with a medium effect size post-intervention. While other psychological measures did not show significant differences, this exploratory analysis revealed favorable trends, particularly in anxiety, spiritual well-being, and post-traumatic growth. At 3-month follow-up, most scales showed a diminished effect compared to post-intervention. Qualitative interviews revealed four themes: a safe and validating environment, acquiring skills and taking action, enhanced well-being, and exposure to memories of cancer. This last dimension was a source of beneficial inner work for most participants, although it was a deeply challenging experience for four women. Participation in the e-MBCR program led to beneficial experiences, notably self-exploration, and enhanced self-efficacy. However, MBIs can also bring up challenging experiences, which are important to acknowledge. NCT04564768.
Comparable studies
Other randomized controlled trials on meditation, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Alterations in Brain and Immune Function Produced by Mindfulness Meditation Healthy employees in a work environment | 2003 | Randomized controlled trial | n = 41 |
| Prevention of relapse/recurrence in major depression by mindfulness-based cognitive therapy. Recovered recurrently depressed patients | 2000 | Randomized controlled trial | n = 145 |
| Open hearts build lives: Positive emotions, induced through loving-kindness meditation, build consequential personal resources. Working adults | 2008 | Randomized controlled trial | n = 139 |
| Short-term meditation training improves attention and self-regulation Undergraduate Chinese students | 2007 | Randomized controlled trial | n = 40 |
| Mindfulness-Based Cognitive Therapy for Depression: Replication and Exploration of Differential Relapse Prevention Effects. Recovered recurrently depressed patients | 2004 | Randomized controlled trial | n = 73 |
Citations in the library
Cites 7
- Mechanisms of mindfulness Journal of Clinical Psychology December 29, 2005
- How Does Mindfulness Meditation Work? Proposing Mechanisms of Action From a Conceptual and Neural Perspective Perspectives on Psychological Science October 14, 2011
- Construct Validity of the Five Facet Mindfulness Questionnaire in Meditating and Nonmeditating Samples Assessment February 29, 2008
- Constructing drug effects: A history of set and setting Drug Science, Policy and Law 2017
- Adaptation of a mindfulness-based intervention for trauma-exposed, unhoused women with substance use disorder. Psychological Trauma: Theory, Research, Practice and Policy December 1, 2024
and 2 more in the library