Efficacy of a single session mindfulness based intervention: A randomized clinical trial.
Mikael Rubin, Caitlin M Fischer, Michael J Telch
PLoS One 2024 DOI: 10.1371/journal.pone.0299300 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Randomized clinical trial Preregistered Peer reviewed |
|---|---|
| Sample size | 91 |
| Population | Adults during the COVID-19 pandemic |
| Interventions | Mindfulness only Mindfulness and compassion |
| Duration | One-hour intervention, 1-week follow-up |
| Topics | Meditation |
| Citations | 21 |
| Key findings | A single-session mindfulness and compassion intervention reduced perceived stress, anxiety, and depression but not loneliness at one-week follow-up. |
Abstract
Loneliness, perceived stress, depression, and anxiety have increased during the COVID-19 pandemic. Many of existing mindfulness and compassion-based intervention are effective, but are time-intensive, decreasing overall accessibility and scalability. Single-session interventions (SSIs) serve as a promising alternative. The current pre-registered randomized clinical trial evaluated a newly developed, manualized, mindfulness-based single-session intervention. 91 adults were randomly assigned to one of three conditions: (1) one-hour mindfulness only telehealth intervention; (b) one-hour mindfulness and compassion telehealth intervention; or (c) one-week waitlist control (before randomization to an active intervention). Intervention sessions were conducted by graduate students in clinical psychology. The primary outcome was self-reported loneliness; secondary outcomes were self-reported perceived stress, depression, and anxiety. Using Bayesian multilevel models, we found that compared to the waitlist-control, the inclusion of a compassion component led to meaningful reductions in perceived stress b = -3.75, 95% HDI [-6.95, -0.59], anxiety b = -3.79, 95% HDI [-6.99, -0.53], and depression b = -3.01, 95% HDI [-5.22, -0.78], but not loneliness at the 1-week follow-up. Results suggest that a single-session mindfulness and compassion intervention may lead to meaningful reductions in perceived stress, symptoms of anxiety, and symptoms of depression, but not loneliness. Implications of these findings are discussed.
Comparable studies
Other randomized controlled trials on meditation, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Alterations in Brain and Immune Function Produced by Mindfulness Meditation Healthy employees in a work environment | 2003 | Randomized controlled trial | n = 41 |
| Prevention of relapse/recurrence in major depression by mindfulness-based cognitive therapy. Recovered recurrently depressed patients | 2000 | Randomized controlled trial | n = 145 |
| Open hearts build lives: Positive emotions, induced through loving-kindness meditation, build consequential personal resources. Working adults | 2008 | Randomized controlled trial | n = 139 |
| Short-term meditation training improves attention and self-regulation Undergraduate Chinese students | 2007 | Randomized controlled trial | n = 40 |
| Mindfulness-Based Cognitive Therapy for Depression: Replication and Exploration of Differential Relapse Prevention Effects. Recovered recurrently depressed patients | 2004 | Randomized controlled trial | n = 73 |
Citations in the library
Cited by 9
- The impact of a mindful compassion program for medical trainees. BMC Medical Education July 1, 2025
- The effectiveness of second-generation mindfulness interventions on anxiety and depression: A systematic review and meta-analysis. Clinical Psychology Review February 1, 2026
- Autonomic and psychophysiological effects of a 13-week mindfulness-based intervention in university students Frontiers in Psychology February 4, 2026
- The Synergistic Contribution of Virtual Companionship to Mindfulness: Evidence from fNIRS-Based Physiological Measures Mindfulness August 20, 2026
- Developing and testing the effectiveness of mindfulness intervention for reducing loneliness in Hong Kong older adults: A hybrid sequential multiple assignment randomized trial, micro randomized trial experimental design study protocol Research Square June 11, 2026
and 4 more in the library
Cites 5
- Construct Validity of the Five Facet Mindfulness Questionnaire in Meditating and Nonmeditating Samples Assessment February 29, 2008
- Clarifying the construct of mindfulness in the context of emotion regulation and the process of change in therapy. Clinical Psychology Science and Practice 2004
- Brief mindfulness training for negative affectivity: A systematic review and meta-analysis. Journal of Consulting and Clinical Psychology June 25, 2018
- Efficacy of a single-session online ACT-based mindfulness intervention among undergraduates in lockdown during the COVID-19 pandemic. Trends in Psychiatry and Psychotherapy February 17, 2023
- Mindfulness training reduces loneliness and increases social contact in a randomized controlled trial Proceedings of the National Academy of Sciences February 11, 2019