EFFECT OF ZOTEPINE ON HEAD-TWITCH INDUCED BY L-5-HYDROXYTRYPTOPHAN, MESCALINE AND 2,5-DIMETHOXY-4-METHYLAMPHETAMINE IN MICE AND RATS
Tsuneyuki Yamamoto, Naoe Tazoe, Showa Ueki, Kyoichi Shimomura, Hisashi Satoh, Jo Mori
The Japanese Journal of Pharmacology 1983 DOI: 10.1016/s0021-5198(19)52515-x (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Mice and rats |
| Interventions | Zotepine cyproheptadine |
| Topics | Mescaline Serotonin |
| Keywords | Cyproheptadine Pharmacology Hallucinogen |
| Citations | 2 |
| Key findings | Zotepine and haloperidol produced potent inhibitory effects on head-twitch induced by L-5HTP, mescaline, and DOM, indicating zotepine has a potent anti-hallucinogenic effect. |
Abstract
The effect of zotepine, a new neuroleptic, on head-twitch induced by L-5-hydroxytryptophan (L-5HTP), mescaline and 2,5-dimethoxy-4-methylamphetamine (DOM) in mice and rats was compared with that of known neuroleptics and the serotonin receptor blocker cyproheptadine. Among the neuroleptics tested, zotepine and halo-peridol produced potent inhibitory effects on head-twitch induced by these three drugs. The results indicate that zotepine has a potent anti-hallucinogenic effect.
Comparable studies
Other preclinical and animal studies on mescaline, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Correlation between the potency of hallucinogens in the mouse head-twitch response assay and their behavioral and subjective effects in other species. C57BL/6J mice | 2020 | Experimental study with dose-response experiments | |
| Brain mechanisms of hallucinogens and entactogens Humans and rats | 2001 | Review | |
| Effects of hallucinogenic agents mescaline and phencyclidine on zebrafish behavior and physiology Zebrafish (Danio rerio) | 2012 | Experimental study | |
| Lysergic Acid Diethylamide- and Mescaline-Induced Attenuation of the Effect of Punishment in the Rat Rats | 1976 | Experimental study | |
| Dihydrobenzofuran Analogues of Hallucinogens. 3. Models of 4-Substituted (2,5-Dimethoxyphenyl)alkylamine Derivatives with Rigidified Methoxy Groups Rats (trained to discriminate saline from LSD tartrate) and rat cortical and... | 1996 | In vivo drug discrimination assay and in vitro radioligand binding assay |
Citations in the library
Cites 2
- Inhibitory effect of chlorpromazine on the syndrome of hyperactivity produced by l‐tryptophan or 5‐methoxy‐N,N‐dimethyltryptamine in rats treated with a monoamine oxidase inhibitor British Journal of Pharmacology December 1, 1971
- The role of central serotonergic mechanisms on head-twitch and backward locomotion induced by hallucinogenic drugs. Pharmacology, Biochemistry, and Behavior January 1981