A PSYCHO-PHARMACOLOGICAL ANALYSIS OF BEHAVIOUR IN RATS
B.d. Gupta, P.c. Dandiya, Mahima Gupta
The Japanese Journal of Pharmacology 1971 DOI: 10.1254/jjp.21.293 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Rats |
| Interventions | methyl phenidate pentylene tetrazol mescaline caffeine pargyline |
| Topics | Mescaline |
| Keywords | Open field Stimulant Amphetamine Imipramine Pharmacology Iproniazid Stimulation |
| Citations | 78 |
| Key findings | Different stimulant drugs produce distinct patterns of behavior in the Open Field Test, with LSD and iproniazid selectively increasing stereotyped ambulation, amphetamine increasing rearing while blocking ambulation and preening, and imipramine inhibiting preening alone. |
Abstract
The Open Field Test situation is reported to produce autonomic nervous system reactivity determined emotional freezing and defecation (1, 2), cortical excitation determined rearing activity (3), and corpus striatum activity determined stereotyped ambulation (4, 5). Thus autonomic depressant drugs reduce emotional freezing (6), cortical excitant drugs augment rearing (7, 8), and hallucinatory drugs facilitate stereotyped ambulation (4). It has been reported (3) that selective stimulation of stereotyped ambulation with suppression of interrupting responses of rearing or preening is a typical action of increasing doses of LSD or iproniazid. This typical drug effect can be differentiated from that of amphetamine which in increasing doses facilitates rearing and simultaneously blocks preening as well as stereotyped ambulation; a third type of drug effect being that of imipramine which in increasing doses inhibits preening but failing to modify ambulation or rearing in rats. In the present study, attempts have been made to extend this approach to other stimulant drugs, i.e. methyl phenidate, pentylene tetrazol, mescaline, caffeine and pargyline for arriving at some definite conclusions regarding the multidimensional Open Field performance and the pharmacological manipulation there of.
Comparable studies
Other preclinical and animal studies on mescaline, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Correlation between the potency of hallucinogens in the mouse head-twitch response assay and their behavioral and subjective effects in other species. C57BL/6J mice | 2020 | Experimental study with dose-response experiments | |
| Brain mechanisms of hallucinogens and entactogens Humans and rats | 2001 | Review | |
| Effects of hallucinogenic agents mescaline and phencyclidine on zebrafish behavior and physiology Zebrafish (Danio rerio) | 2012 | Experimental study | |
| Lysergic Acid Diethylamide- and Mescaline-Induced Attenuation of the Effect of Punishment in the Rat Rats | 1976 | Experimental study | |
| Dihydrobenzofuran Analogues of Hallucinogens. 3. Models of 4-Substituted (2,5-Dimethoxyphenyl)alkylamine Derivatives with Rigidified Methoxy Groups Rats (trained to discriminate saline from LSD tartrate) and rat cortical and... | 1996 | In vivo drug discrimination assay and in vitro radioligand binding assay |