Lysergic Acid Diethylamide (LSD-25) Antagonists
A M A Archives of Neurology & Psychiatry February 1, 1958 DOI: 10.1001/archneurpsyc.1958.02340020081015 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Siamese fighting fish and humans |
| Intervention | 1-methyl-d-lysergic acid diethylamide (MLD-41) |
| Topics | LSD |
| Keywords | Pharmacology |
| Citations | 31 |
| Key findings | MLD-41 produces effects similar to LSD-25 in fish and humans but is less potent, and its prior administration induces tolerance to LSD-25 in humans. |
Abstract
A. Introduction It has been shown1,2that 2 mg. of crude beef brain extract per milliliter of water blocks the usual effect of 2μg of LSD-25 per milliliter in the outside liquid on the Siamese fighting fish.* The experiments to be reported here are the study of a blocking effect probably produced by another mechanism: the development of tolerance3to LSD-25 in man by the prior administration for a period of days of a compound similar to LSD-25. This compound, 1-methyl-d-lysergic acid diethylamide (MLD-41), produces in man reactions indistinguishable from LSD-25 but has a higher reaction threshold. It will be shown on the basis of our data that MLD-41 affects both the Siamese fighting fish and man in a manner similar to LSD-25. However, there are important differences; in the fish it is about 1/10 as effective as LSD-25, whereas it is approximately 1/3 as effective in man.
Comparable studies
Other experimental studies on LSD, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Neural correlates of the LSD experience revealed by multimodal neuroimaging. Human participants | 2016 | Experimental study | |
| Crystal structure of an LSD-bound human serotonin receptor | 2017 | Experimental study with structural biology and molecular dynamics simulations | |
| Lysergic Acid Diethylamide: Sensitive Neuronal Units in the Midbrain Raphe Midbrain neurons containing serotonin | 1968 | Experimental study | |
| Connectome-harmonic decomposition of human brain activity reveals dynamical repertoire re-organization under LSD. Human brain | 2017 | Experimental study | |
| LSD-Assisted Psychotherapy in Patients with Terminal Cancer Cancer patients | 1973 | Experimental study | n = 60 |
Citations in the library
Cited by 9
- The Pharmacology of Lysergic Acid Diethylamide: A Review CNS Neuroscience & Therapeutics November 11, 2008
- Effect of Hallucinogens on Unconditioned Behavior Current Topics in Behavioral Neurosciences 2016
- Antagonism of histamine-activated adenylate cyclase in brain by D-lysergic acid diethylamide. Proceedings of the National Academy of Sciences December 1, 1977
- Acquired and Crossed Tolerance to Mescaline, LSD-25, and BOL-148 Archives of General Psychiatry September 1, 1959
- Production of Cross-Tolerance to Psychosis-Producing Doses of Lysergic Acid Diethylamide and Psilocybin The Journal of Psychology 1960
and 4 more in the library