Effects of Lysergic Acid Diethylamide (LSD) on the Time Sense of Normals
A M A Archives of Neurology & Psychiatry September 1, 1957 DOI: 10.1001/archneurpsyc.1957.02330390103013 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Normal subjects |
| Intervention | Lysergic acid diethylamide (LSD) |
| Dose | moderate to low doses |
| Topics | LSD |
| Keywords | Schizophrenia object-oriented programming Time perception Audiology Sense electronics Population Stereochemistry |
| Citations | 21 |
| Key findings | Moderate to low doses of LSD produce alterations in time perception in normal subjects, specifically overestimation of short audible durations, in the direction characteristic of schizophrenia. |
Abstract
Introduction Much of the interest in lysergic acid diethylamide (LSD) is due to its capacity to produce schizophrenic-like behavior when administered in extremely small quantities. 4,6 Among the reported changes resulting from LSD have been alterations in time perception. DeShon, Rinkel, and Solomon, 1 found changes in the form of experiences of acceleration, retardation, or nonexistence of time, while true disorientation was not observed. The subjects of Hoch, Cattell, and Pennes 3 reported the passage of time as slowed, an experience not uncommon to schizophrenic patients. An objective study of the time sense of schizophrenics 5 indicated that this population overestimates short audible durations to a significantly greater degree than do normal controls. The purpose of the present investigation was to determine whether moderate to low doses of LSD produce alterations in the time sense of normal subjects in the direction characteristic of schizophrenia, using the same method as reported
Comparable studies
Other experimental studies on LSD, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Neural correlates of the LSD experience revealed by multimodal neuroimaging. Human participants | 2016 | Experimental study | |
| Crystal structure of an LSD-bound human serotonin receptor | 2017 | Experimental study with structural biology and molecular dynamics simulations | |
| Lysergic Acid Diethylamide: Sensitive Neuronal Units in the Midbrain Raphe Midbrain neurons containing serotonin | 1968 | Experimental study | |
| Connectome-harmonic decomposition of human brain activity reveals dynamical repertoire re-organization under LSD. Human brain | 2017 | Experimental study | |
| LSD-Assisted Psychotherapy in Patients with Terminal Cancer Cancer patients | 1973 | Experimental study | n = 60 |
Citations in the library
Cited by 8
- The effects of microdose LSD on time perception: a randomised, double-blind, placebo-controlled trial Psychopharmacology November 26, 2018
- A Deep-Dream Virtual Reality Platform for Studying Altered Perceptual Phenomenology Scientific Reports November 16, 2017
- The therapeutic potential of microdosing psychedelics in depression Therapeutic Advances in Psychopharmacology 2020
- Serotonergic hallucinogens as translational models relevant to schizophrenia The International Journal of Neuropsychopharmacology August 13, 2013
- Influence of Lysergic Acid Diethylamide (LSD-25) on Subjective Time Archives of General Psychiatry November 1, 1959
and 3 more in the library