Studies in the Effect of Lysergic Acid Diethylamide (LSD-25)
A M A Archives of Neurology & Psychiatry May 1, 1958 DOI: 10.1001/archneurpsyc.1958.02340050108013 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Schizophrenics and normal adults |
| Intervention | Lysergic acid diethylamide (LSD-25) |
| Topics | LSD |
| Citations | 30 |
| Key findings | LSD alters size perception of one's own body and objects in space, reflecting changes in organismic state. |
Abstract
This study is one of a series of experiments designed to inquire into some of the perceptual effects of administration of lysergic acid diethylamide (LSD-25)* to schizophrenics and normal adults. Specifically, the study deals with the effect of LSD on size perception of one's own body and objects in space. This problem is approached within the framework of organismic behavior theory, viz., the sensory-tonic field theory of perception and the developmental theory. According to the sensory-tonic theory, perception is an experience that corresponds to a particular relation between the organismic state and the impinging stimulus. From this general formulation it follows that a change in either the external stimuli or the organismic state will produce a change in perception. That alterations in organismic state produced by LSD are reflected by changes in perception has been demonstrated by us in another experiment, concerned with perception of verticality (with the same groups
Comparable studies
Other experimental studies on LSD, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Neural correlates of the LSD experience revealed by multimodal neuroimaging. Human participants | 2016 | Experimental study | |
| Crystal structure of an LSD-bound human serotonin receptor | 2017 | Experimental study with structural biology and molecular dynamics simulations | |
| Lysergic Acid Diethylamide: Sensitive Neuronal Units in the Midbrain Raphe Midbrain neurons containing serotonin | 1968 | Experimental study | |
| Connectome-harmonic decomposition of human brain activity reveals dynamical repertoire re-organization under LSD. Human brain | 2017 | Experimental study | |
| LSD-Assisted Psychotherapy in Patients with Terminal Cancer Cancer patients | 1973 | Experimental study | n = 60 |