Neuron
July 5, 2021
Ling-Xiao Shao, Clara Liao, Ian Gregg et al.
589 citations
Summary Psilocybin is a serotonergic psychedelic with untapped therapeutic potential. There are hints that the use of psychedelics can produce neural adaptations, although the extent and time scale of the impact in a mammalian brain are unknown. In this study, we used chronic two-photon microscopy to image longitudinally the apical dendritic spines of layer 5 pyramidal neurons in the mouse...
Neuron
December 1, 2020
Jennifer D. Whitesell, Adam Liska, L. Coletta et al.
Summary The evolutionarily conserved default mode network (DMN) is a distributed set of brain regions coactivated during resting states that is vulnerable to brain disorders. How disease affects the DMN is unknown, but detailed anatomical descriptions could provide clues. Mice offer an opportunity to investigate structural connectivity of the DMN across spatial scales with cell-type resolution....
Neuron
January 22, 2020
Michelle J. Redinbaugh, Jessica M. Phillips, Niranjan A. Kambi et al.
SUMMARY: Functional MRI and electrophysiology studies suggest consciousness depends on large-scale thalamocortical and corticocortical interactions. However, it is unclear how neurons in different cortical layers and circuits contribute. We simultaneously recorded from central lateral thalamus (CL) and across layers of frontoparietal cortex in awake, sleeping and anesthetized macaques. We found...
Neuron
March 1, 2019
John H. Krystal, Chadi G. Abdallah, Gerard Sanacora et al.
443 citations
Ketamine is the first exemplar of a rapid-acting antidepressant with efficacy for treatment-resistant symptoms of mood disorders. Its discovery emerged from a reconceptualization of the biology of depression. Neurobiological insights into ketamine efficacy shed new light on the mechanisms underlying antidepressant efficacy. The rapid, profound, and sustainable antidepressant effects of ketamine...
Neuron
April 28, 2011
Salvatore M Aglioti, Matteo Candidi
In this issue of Neuron, Ionta et al. (2011) combine behavioral and fMRI approaches with anatomical lesion data to show that illusory perception of one's own body from an external point of view or at a different physical location is linked to modulation of neural activity in the temporo-parietal-junction, a cortical region fundamental to body-consciousness.
Neuron
April 28, 2011
Stanislas Dehaene, Jean-Pierre Changeux
Recent experimental studies and theoretical models have begun to address the challenge of establishing a causal link between subjective conscious experience and measurable neuronal activity. The present review focuses on the well-delimited issue of how an external or internal piece of information goes beyond nonconscious processing and gains access to conscious processing, a transition...
Neuron
April 28, 2011
Silvio Ionta, Lukas Heydrich, Bigna Lenggenhager et al.
Self-consciousness has mostly been approached by philosophical enquiry and not by empirical neuroscientific study, leading to an overabundance of diverging theories and an absence of data-driven theories. Using robotic technology, we achieved specific bodily conflicts and induced predictable changes in a fundamental aspect of self-consciousness by altering where healthy subjects experienced...
Neuron
February 10, 2011
Patrick Haggard
In this issue of Neuron, Fried et al. report electrical recordings from single neurons in several areas of the human medial frontal lobe prior to voluntary movement. These data shed important new light on the neuronal mechanisms of human volition and on the hotly debated relation between consciousness and will.
Neuron
February 1, 2010
Cosimo Urgesi, Salvatore M. Aglioti, Miran Skrap et al.
220 citations
The predisposition of human beings toward spiritual feeling, thinking, and behaviors is measured by a supposedly stable personality trait called self-transcendence. Although a few neuroimaging studies suggest that neural activation of a large fronto-parieto-temporal network may underpin a variety of spiritual experiences, information on the causative link between such a network and spirituality...
Neuron
February 1, 2007
Javier González-Maeso, Noelia V Weisstaub, Mingming Zhou et al.
Hallucinogens, including mescaline, psilocybin, and lysergic acid diethylamide (LSD), profoundly affect perception, cognition, and mood. All known drugs of this class are 5-HT(2A) receptor (2AR) agonists, yet closely related 2AR agonists such as lisuride lack comparable psychoactive properties. Why only certain 2AR agonists are hallucinogens and which neural circuits mediate their effects are...
Neuron
March 1, 1999
R. Grailhe, C. Waeber, S. Dulawa et al.
In order to determine the distribution and function of the 5-HT5A serotonin receptor subtype, we generated knockout mice lacking the 5-HT5A gene. Comparative autoradiography studies of brains of wild-type (wt) and 5-HT5A knockout (5A-KO) mice revealed the existence of binding sites with high affinity for [125I]LSD that correspond to 5-HT5A receptors and that are concentrated in the olfactory...