Research published in Journal of Neuroscience (page 6)

Glial Cell Line-Derived Neurotrophic Factor Mediates the Desirable Actions of the Anti-Addiction Drug Ibogaine against Alcohol Consumption

Journal of Neuroscience January 19, 2005 Dao‐yao He, Nancy N. H. Mcgough, Ajay Ravindranathan et al. 181 citations

Alcohol addiction manifests as uncontrolled drinking despite negative consequences. Few medications are available to treat the disorder. Anecdotal reports suggest that ibogaine, a natural alkaloid, reverses behaviors associated with addiction including alcoholism; however, because of side effects, ibogaine is not used clinically. In this study, we first characterized the actions of ibogaine on...

DOI: 10.1523/jneurosci.3959-04.2005 Full text Ventral tegmental area Neurotrophic factors Pharmacology Self-administration +3

Ketamine Induces Dopamine-Dependent Depression of Evoked Hippocampal Activity in the Nucleus Accumbens in Freely Moving Rats

Journal of Neuroscience January 12, 2005 Mark J. Hunt, Karima Kessal, Rene Garcia

Noncompetitive NMDA receptor antagonists, such as ketamine, induce a transient schizophrenia-like state in healthy individuals and exacerbate psychosis in schizophrenic patients. In rodents, noncompetitive NMDA receptor antagonists induce a behavioral syndrome that represents an experimentally valid model of schizophrenia. Current experimental evidence has implicated the nucleus accumbens in...

DOI: 10.1523/jneurosci.3800-04.2005

3,4-Methylenedioxymethamphetamine (Ecstasy) Inhibits Dyskinesia Expression and Normalizes Motor Activity in 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Treated Primates

Journal of Neuroscience October 8, 2003 Mahmoud M. Iravani, Michael S. Jackson, Mikko Kuoppamäki et al. 105 citations

Ecstasy [3,4-methylenedioxymethamphetamine (MDMA)] was shown to prolong the action of l -3,4-dihydroxyphenylalanine ( l -DOPA) while suppressing dyskinesia in a single patient with Parkinson's disease (PD). The clinical basis of this effect of MDMA is unknown but may relate to its actions on either dopaminergic or serotoninergic systems in brain. In normal, drug-naive common marmosets, MDMA...

DOI: 10.1523/jneurosci.23-27-09107.2003 Full text MDMA Serotonergic Ecstasy Serotonin +6

Transcriptome Fingerprints Distinguish Hallucinogenic and Nonhallucinogenic 5-Hydroxytryptamine 2A Receptor Agonist Effects in Mouse Somatosensory Cortex

Journal of Neuroscience October 1, 2003 Javier González-Maeso, Tony Yuen, Barbara J. Ebersole et al. 295 citations

Most neuropharmacological agents and many drugs of abuse modulate the activity of heptahelical G-protein-coupled receptors. Although the effects of these ligands result from changes in cellular signaling, their neurobehavioral activity may not correlate with results of in vitro signal transduction assays. 5-Hydroxytryptamine 2A receptor (5-HT2AR) partial agonists that have similar...

DOI: 10.1523/jneurosci.23-26-08836.2003 Full text Lysergic acid diethylamide Signal transduction Transcriptome Receptor +4

Functional tolerance and blockade of long-term depression at synapses in the nucleus accumbens after chronic cannabinoid exposure.

Journal of Neuroscience June 15, 2003 Alexander F. Hoffman, Murat Oz, Tara Caulder et al.

The rewarding properties of the psychoactive constituents of marijuana, termed "cannabinoids," may reflect actions on synaptic transmission in the nucleus accumbens (NAc). Furthermore, long-term changes in these synapses may support the addictive process. Excitatory and inhibitory synapses are acutely inhibited by cannabinoids in the NAc, and endogenous cannabinoids (endocannabinoids) play a...

DOI: 10.1523/jneurosci.23-12-04815.2003 Full text

Control of Serotonergic Function in Medial Prefrontal Cortex by Serotonin-2A Receptors through a Glutamate-Dependent Mechanism

Journal of Neuroscience December 15, 2001 Raúl Martín‐Ruiz, M. Victoria Puig, Pau Celada et al. 335 citations

We examined the in vivo effects of the hallucinogen 4-iodo-2,5-dimethoxyamphetamine (DOI). DOI suppressed the firing rate of 7 of 12 dorsal raphe (DR) serotonergic (5-HT) neurons and partially inhibited the rest (ED(50) = 20 microg/kg, i.v.), an effect reversed by M100907 (5-HT(2A) antagonist) and picrotoxinin (GABA(A) antagonist). DOI (1 mg/kg, s.c.) reduced the 5-HT release in medial...

DOI: 10.1523/jneurosci.21-24-09856.2001 Full text Serotonergic Serotonin Nbqx Ampa receptor +5

The Role of Kv1.2-Containing Potassium Channels in Serotonin-Induced Glutamate Release from Thalamocortical Terminals in Rat Frontal Cortex

Journal of Neuroscience December 15, 2001 Evelyn K. Lambe, George K. Aghajanian 111 citations

Serotonin 5-HT 2A receptors have been implicated in psychiatric illness and the psychotomimetic effects of hallucinogens. In brain slices, focal stimulation of 5-HT 2A receptors in rat prefrontal cortex results in dramatically increased glutamate release onto layer V pyramidal neurons, as measured by an increase in “spontaneous” (nonelectrically evoked) EPSCs. This glutamate release is blocked...

DOI: 10.1523/jneurosci.21-24-09955.2001 Full text Glutamate receptor Potassium channel Channel blocker Tetrodotoxin +2

Absence of delta -9-tetrahydrocannabinol dysphoric effects in dynorphin-deficient mice.

Journal of Neuroscience December 1, 2001 Andreas Zimmer, E Valjent, M Konig et al.

The involvement of dynorphin on Delta-9-tetrahydrocannabinol (THC) and morphine responses has been investigated by using mice with a targeted inactivation of the prodynorphin (Pdyn) gene. Dynorphin-deficient mice show specific changes in the behavioral effects of THC, including a reduction of spinal THC analgesia and the absence of THC-induced conditioned place aversion. In contrast, acute and...

DOI: 10.1523/jneurosci.21-23-09499.2001 Full text

Cutaneous Vasoconstriction Contributes to Hyperthermia Induced by 3,4-Methylenedioxymethamphetamine (Ecstasy) in Conscious Rabbits

Journal of Neuroscience November 1, 2001 Nigel P. Pedersen, W.w. Blessing 120 citations

3,4-Methylenedioxymethamphetamine (MDMA; "Ecstasy") increases body temperature. This process could be associated with increased cutaneous blood flow, as normally occurs with exercise-induced hyperthermia. Alternatively, an MDMA-induced fall in cutaneous blood flow could contribute to the hyperthermia by diminishing normal heat transfer from the body to the environment. We investigated these...

DOI: 10.1523/jneurosci.21-21-08648.2001 Full text MDMA Ecstasy Vasoconstriction Hyperthermia +2

5-HT2A Receptors Stimulate ACTH, Corticosterone, Oxytocin, Renin, and Prolactin Release and Activate Hypothalamic CRF and Oxytocin-Expressing Cells

Journal of Neuroscience May 15, 2001 Louis D. van de Kar, Adil Javed, Ya-Hong Zhang et al.

The 5-HT2A/2C agonist (±)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane HCl (DOI) stimulates hypothalamic neurons to increase the secretion of several hormones. This study addressed two questions: 1) are the neuroendocrine effects of DOI mediated via activation of 5-HT2A receptors; and 2) which neurons are activated by 5-HT2A receptors. The 5-HT2A antagonist...

DOI: 10.1523/jneurosci.21-10-03572.2001 Full text

Cannabinoids inhibit the formation of new synapses between hippocampal neurons in culture.

Journal of Neuroscience May 15, 2001 D Kim, S A Thayer

The principal psychoactive ingredient in marijuana, Delta(9)-tetrahydrocannabinol, has been shown to inhibit adenylyl cyclase activity in vitro and can lead to impairment of memory in vivo. cAMP-induced changes in synaptic plasticity are thought to underlie memory formation. We examined the effects of cannabinoid receptor agonists on forskolin-induced formation of new synapses between rat...

DOI: 10.1523/jneurosci.21-10-j0004.2001 Full text

3,4-Methylenedioxymethamphetamine (Ecstasy)-Induced Learning and Memory Impairments Depend on the Age of Exposure during Early Development

Journal of Neuroscience May 1, 2001 Harry W. Broening, Laronda L. Morford, Sandra L. Inman-Wood et al. 141 citations

Use of 3,4-methylenedioxymethamphetamine (MDMA; ecstasy) has increased dramatically in recent years, yet little is known about its effects on the developing brain. Neonatal rats were administered MDMA on days 1–10 or 11–20 (analogous to early and late human third trimester brain development). MDMA exposure had no effect on survival but did affect body weight gain during treatment. After...

DOI: 10.1523/jneurosci.21-09-03228.2001 Full text MDMA Ecstasy Serotonin Offspring +3

DOI-Induced Activation of the Cortex: Dependence on 5-HT2AHeteroceptors on Thalamocortical Glutamatergic Neurons

Journal of Neuroscience December 1, 2000 Jennifer L. Scruggs, Sachin Patel, Michael Bubser et al. 154 citations

Administration of the hallucinogenic 5-HT 2A/2C agonist 1-[2,5-dimethoxy-4-iodophenyl]-2-aminopropane (DOI) induces expression of Fos protein in the cerebral cortex. To understand the mechanisms subserving this action of DOI, we examined the consequences of pharmacological and surgical manipulations on DOI-elicited Fos expression in the somatosensory cortex of the rat. DOI dose-dependently...

DOI: 10.1523/jneurosci.20-23-08846.2000 Full text Glutamatergic Ampa receptor Thalamus Somatosensory system +7

Increased Synchronization of Neuromagnetic Responses during Conscious Perception

Journal of Neuroscience July 1, 1999 Ramesh Srinivasan, D. Patrick Russell, Gerald M. Edelman et al. 438 citations

In binocular rivalry, the observer views two incongruent images, one through each eye, but is conscious of only one image at a time. The image that is perceptually dominant alternates every few seconds. We used this phenomenon to investigate neural correlates of conscious perception. We presented a red vertical grating to one eye and a blue horizontal grating to the other eye, with each grating...

DOI: 10.1523/jneurosci.19-13-05435.1999 Full text Magnetoencephalography Stimulus psychology Binocular rivalry Grating +7

Rat strain differences in the ability to disrupt sensorimotor gating are limited to the dopaminergic system, specific to prepulse inhibition, and unrelated to changes in startle amplitude or nucleus accumbens dopamine receptor sensitivity.

Journal of Neuroscience July 1, 1999 G G Kinney, L O Wilkinson, K L Saywell et al.

Previous studies indicate that a variety of pharmacological agents interfere with the prepulse inhibition of the acoustic startle (PPI) response including phencyclidine (PCP), 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT), amphetamine, and apomorphine. Strain differences have been observed in the ability of apomorphine to disrupt PPI, although the degree to which these strain differences...

DOI: 10.1523/jneurosci.19-13-05644.1999 Full text

Altered Serotonin Innervation Patterns in the Forebrain of Monkeys Treated with (±)3,4-Methylenedioxymethamphetamine Seven Years Previously: Factors Influencing Abnormal Recovery

Journal of Neuroscience June 15, 1999 George Hatzidimitriou, Una D. Mccann, George A. Ricaurte 338 citations

The recreational drug (±)3,4-methylenedioxymethamphetamine (MDMA, “Ecstasy”) is a potent and selective brain serotonin (5-HT) neurotoxin in animals and, possibly, in humans. The purpose of the present study was to determine whether brain 5-HT deficits persist in squirrel monkeys beyond the 18-month period studied previously and to identify factors that influence recovery of injured 5-HT axons....

DOI: 10.1523/jneurosci.19-12-05096.1999 Full text MDMA Serotonin Ecstasy Serotonergic +6

Corticolimbic dopamine neurotransmission is temporally dissociated from the cognitive and locomotor effects of phencyclidine.

Journal of Neuroscience July 15, 1998 B Adams, Bita Moghaddam

The behavioral syndrome produced by phencyclidine (PCP) and its analog ketamine represents a pharmacological model for some aspects of schizophrenia. Despite the multifaceted properties of these drugs, the main mechanism for their psychotomimetic and cognitive-impairing effects has been thought heretofore to involve the corticolimbic dopamine system. The present study examined the temporal...

DOI: 10.1523/jneurosci.18-14-05545.1998 Full text

Small Changes in Ambient Temperature Cause Large Changes in 3,4-Methylenedioxymethamphetamine (MDMA)-Induced Serotonin Neurotoxicity and Core Body Temperature in the Rat

Journal of Neuroscience July 1, 1998 Jessica E. Malberg, Lewis S. Seiden 344 citations

The amphetamine derivative 3,4-methylenedioxymethamphetamine (MDMA) is a drug of abuse and has been shown to be neurotoxic to 5-HT terminals in many species. MDMA-engendered neurotoxicity has been shown to be affected by both ambient temperature and core body temperature. We now report that small (2°C) changes in ambient temperature produce changes in core temperature in MDMA-treated rats, but...

DOI: 10.1523/jneurosci.18-13-05086.1998 Full text MDMA Serotonin Neurotoxicity Core optical fiber +5

The Olivocerebellar Projection Mediates Ibogaine-Induced Degeneration of Purkinje Cells: A Model of Indirect, Trans-Synaptic Excitotoxicity

Journal of Neuroscience November 15, 1997 Elizabeth O’hearn, Mark E. Molliver 158 citations

Ibogaine, an indole alkaloid that causes hallucinations, tremor, and ataxia, produces cerebellar neurotoxicity in rats, manifested by degeneration of Purkinje cells aligned in narrow parasagittal bands that are coextensive with activated glial cells. Harmaline, a closely related alkaloid that excites inferior olivary neurons, causes the same pattern of Purkinje cell degeneration, providing a...

DOI: 10.1523/jneurosci.17-22-08828.1997 Full text Climbing fiber Purkinje cell Cerebellum Harmaline +7

Activation of Glutamatergic Neurotransmission by Ketamine: A Novel Step in the Pathway from NMDA Receptor Blockade to Dopaminergic and Cognitive Disruptions Associated with the Prefrontal Cortex

Journal of Neuroscience April 15, 1997 Bita Moghaddam, Barbara W. Adams, Anita Verma et al. 1,813 citations

Subanesthetic doses of ketamine, a noncompetitive NMDA receptor antagonist, impair prefrontal cortex (PFC) function in the rat and produce symptoms in humans similar to those observed in schizophrenia and dissociative states, including impaired performance of frontal lobe-sensitive tests. Several lines of evidence suggest that ketamine may impair PFC function in part by interacting with...

DOI: 10.1523/jneurosci.17-08-02921.1997 Full text Ketamine Nmda receptor Glutamatergic Kainate receptor +9

5-HT2AReceptor-Mediated Regulation of Brain-Derived Neurotrophic Factor mRNA in the Hippocampus and the Neocortex

Journal of Neuroscience April 15, 1997 Vidita A Vaidya, Gerard J. Marek, George K. Aghajanian et al. 482 citations

The influence of 5-HT receptor agonists on the expression of BDNF in brain was determined. Administration of a hallucinogenic 5-HT2A /2C receptor agonist, but not a 5-HT1A receptor agonist, resulted in a significant but differential regulation of BDNF mRNA levels in hippocampus and neocortex. In the hippocampus, the 5-HT2A /2C receptor agonist significantly decreased BDNF mRNA expression in the...

DOI: 10.1523/jneurosci.17-08-02785.1997 Full text Neocortex Hippocampus Brain-derived neurotrophic factor Neurotrophic factors +2

Rewarding actions of phencyclidine and related drugs in nucleus accumbens shell and frontal cortex.

Journal of Neuroscience May 1, 1996 W A Carlezon, R A Wise

Rats learned to lever-press when such behavior was reinforced by microinjections of phencyclidine (PCP) directly into the ventromedial (shell) region of nucleus accumbens, indicating that the drug has direct rewarding actions in that region. Separate groups of rats learned to lever-press when reinforced with microinjections of dizoclipine (MK-801) or...

DOI: 10.1523/jneurosci.16-09-03112.1996 Full text

NMDA receptor antagonists impair prefrontal cortex function as assessed via spatial delayed alternation performance in rats: modulation by dopamine.

Journal of Neuroscience 1996 A Verma, B Moghaddam

The present study was performed to assess the role of excitatory amino acid and dopamine receptors on associative functions of the prefrontal cortex (PFC) of the rat. Spatial delayed alternation was used as a PFC-sensitive cognitive task. In addition, in vivo microdialysis was used to assess the release of dopamine in the PFC. The noncompetitive NMDA antagonists ketamine (10-30 mg/kg) and...

DOI: 10.1523/jneurosci.16-01-00373.1996 Full text Ketamine Prefrontal cortex Neurons Animals +7

Reorganization of ascending 5-HT axon projections in animals previously exposed to the recreational drug (+/-)3,4-methylenedioxymethamphetamine (MDMA, "ecstasy")

Journal of Neuroscience August 1, 1995 Christina Weide Fischer, George Hatzidimitriou, J Wlos et al. 269 citations

The recreational drug (+/)3,4-methylenedioxymethamphetamine (MDMA, “ecstasy”) is a methamphetamine derivative that selectively destroys central 5-HT axons and axon terminals in animals and, possibly, humans. The fate of 5-HT neurons following MDMA injury is uncertain. In particular, while it is known that central 5-HT axons can undergo regenerative sprouting after MDMA injury, it has not been...

DOI: 10.1523/jneurosci.15-08-05476.1995 Full text MDMA Ecstasy Recreational drug Hallucinogen +2

Cerebellar toxicity of phencyclidine

Journal of Neuroscience March 1, 1995 Riitta Näkki, Jari Koıstınaho, FR Sharp et al. 68 citations

Phencyclidine (PCP), dizocilpine maleate (MK801), and other NMDA antagonists are toxic to neurons in the posterior cingulate and retrosplenial cortex. To determine if additional neurons are damaged, the distribution of microglial activation and 70 kDa heat shock protein (HSP70) induction was studied following the administration of PCP and MK801 to rats. PCP (10-50 mg/kg) induced microglial...

DOI: 10.1523/jneurosci.15-03-02097.1995 Full text

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