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Frontiers in Psychiatry

ISSN 1664-0640

440 papers in the library · 7,744 citations · publishing 2011-2026

Papers

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Differences between users' and addiction medicine experts' harm and benefit assessments of licit and illicit psychoactive drugs: Input for psychoeducation and legalization/restriction debates.

Frontiers in Psychiatry 2022 Udo Bonnet, Michael Specka, Ann-Kristin Kanti et al. 4 citations

There is a lack of benefit/harm assessments of illicit and licit psychoactive substances performed by substance-dependent users in comparison to addiction medicine experts. We extended the analyses of substance harm/benefit assessments of German addiction medicine experts (N = 101), in parts reported recently in this journal [doi.org/10.3389/fpsyt.2020.59219], by the perspectives of...

Disembodied Language in Early-Onset Schizophrenia.

Frontiers in Psychiatry 2022 Przemysław Zakowicz, Maria Skibińska, Joanna Pawlak 3 citations

A recent view on schizophrenia phenomenology underlines the impaired relations between the mind and the body. An aberrant feeling of ipseity may be the real source of suffering of the patients from psychosis and impacts general symptomatology. The disturbed connection between thinking processes and environmental stimuli may lead to language disembodiment. In the study, we aimed to...

Consciousness alterations in a cohort of young Swiss men: Associations with substance use and personality traits.

Frontiers in Psychiatry 2022 Marianthi Lousiana Deligianni, Joseph Studer, Gerhard Gmel et al. 1 citation

Substance-induced consciousness alterations (CA) have mainly been studied among users of psychedelics but not among people using street drugs. Explore occurrences of three different types of substance-induced CA [ego dissolution (ED), visual pseudo-hallucinations (VPH), anxiety/paranoia (A/P)] and their perceived influences on life, together with their associations with substance use and...

Paving the way for systemic phenomenological psychiatry - the forgotten heritage of Wolfgang Blankenburg.

Frontiers in Psychiatry 2022 Samuel Thoma, Michael Konrad, Lisa C. Fellin et al.

Phenomenological psychopathology focuses on the first-person experience of mental disorders. Although it is in principle descriptive, it also entails an explanatory dimension: single psychological symptoms are conceived as genetically arising from a holistic structure of personal experience, i.e., the patient's being-in-the-world - and of its dynamic unfolding over time. Yet both classical and...

Case report: Medical student types journals during ketamine infusions for suicidal ideation, treatment-resistant depression, post-traumatic stress disorder, and generalized anxiety disorder.

Frontiers in Psychiatry 2022 Joshua Willms, Ben McCauley, Lindsay Kerr et al.

Suicide is the most common cause of death in male resident physicians and the second most common cause of death in resident physicians overall. Physicians also experience high rates of major depressive disorder (MDD), post-traumatic stress disorder (PTSD), and burnout. These conditions frequently develop during medical school, and threaten not only physicians but the patients they care for. A...

Corrigendum: A cohort-based case report: The impact of ketamine-assisted therapy embedded in a community of practice framework for healthcare providers with PTSD and depression.

Frontiers in Psychiatry 2022 Shannon Dames, Pamela Kryskow, Crosbie Watler correction

Corrigendum: A Cohort-Based Case Report: The Impact of Ketamine-Assisted Therapy Embedded in a Community of Practice Framework for Healthcare Providers with PTSD and DepressionError in Figure/TableIn the published article, there was an error in Figure 2 as published. The PTSD label on the legend that is imbedded in the figure was on the legend component of the figure was posted on the anxiety...

The incubus phenomenon: Prevalence, frequency and risk factors in psychiatric inpatients and university undergraduates.

Frontiers in Psychiatry 2022 Marc L Molendijk, Ouarda Bouachmir, Harriët Montagne et al.

The incubus phenomenon is a paroxysmal sleep-related disorder characterized by the visuotactile sensation of a person or entity exerting pressure on one's thorax during episodes of sleep paralysis and (apparent) wakefulness. This terrifying phenomenon is relatively unknown even though a previous meta-analysis indicated a lifetime prevalence of 0.11 for individuals in the general population and...

What is better for psychiatry: Titrated or fixed concentrations of nitrous oxide?

Frontiers in Psychiatry 2022 Mark A Gillman

Medication dosages are crucial-no single dose fits all. My paper compares the safety, scientific and practical applicability of fixed 25-50% concentrations of nitrous oxide (N2O) with the variable titrated concentrations of Psychotropic Analgesic N2O (PAN), as used in dentistry, and neuropsychiatry. A crucial difference is that PAN is always titrated, via an open circuit (nasal mask), to the...

Erratum: A Spectrum of Selves Reinforced in Multilevel Coherence: A Contextual Behavioural Response to the Challenges of Psychedelic-Assisted Therapy Development

Frontiers in Psychiatry December 24, 2021 Frontiers Production Office correction

Due to a production error, the word 'story' was misspelled in the article. A correction has been made to all instances of 'storey' and 'storeys' in the article. They have been corrected to 'story' and 'stories'.Due to a production error, reference citation (1) was incorrectly linked in the Introduction, line 3 and line 5. The citation on line 3 has now been linked to the corresponding...

Substance-Induced Psychoses: An Updated Literature Review

Frontiers in Psychiatry December 23, 2021 A. Fiorentini, Filippo Cantù, Camilla Crisanti et al. 123 citations

Background: On the current psychopharmacological panorama, the variety of substances able to provoke an episode of acute psychosis is rapidly increasing. Such psychotic episodes are classified according to the major category of symptoms: positive, negative, or cognitive psychotic episodes. On one hand, the abuse of methamphetamines, cannabis, and cocaine plays a big role in increasing the...

Psychedelic Therapy's Transdiagnostic Effects: A Research Domain Criteria (RDoC) Perspective

Frontiers in Psychiatry December 17, 2021 John R. Kelly, Claire M. Gillan, Jack Prenderville et al. 66 citations

Accumulating clinical evidence shows that psychedelic therapy, by synergistically combining psychopharmacology and psychological support, offers a promising transdiagnostic treatment strategy for a range of disorders with restricted and/or maladaptive habitual patterns of emotion, cognition and behavior, notably, depression (MDD), treatment resistant depression (TRD) and addiction disorders,...

A Spectrum of Selves Reinforced in Multilevel Coherence: A Contextual Behavioural Response to the Challenges of Psychedelic-Assisted Therapy Development

Frontiers in Psychiatry December 7, 2021 Henry J. Whitfield 27 citations

Psychedelic-assisted therapy research for depression and PTSD has been fast tracked in the United States with the Food and Drugs Administration (FDA) granting breakthrough designations for MDMA (post-traumatic stress disorder) and psilocybin (major depressive disorder). The psychotherapeutic treatments accompanying these psychedelics have not been well-studied and remain controversial. This...

Clinical Investigation on the Impact of Cannabis Abuse on Thyroid Hormones and Associated Psychiatric Manifestations in the Male Population

Frontiers in Psychiatry December 3, 2021 Anum Muzaffar, Sami Ullah, Fazal Subhan et al. 12 citations

Cannabis abuse is a common public health issue and may lead to considerable adverse effects. Along with other effects, the dependence on cannabis consumption is a serious problem which has significant consequences on biochemical and clinical symptoms. This study intends to evaluate the harmful effects of the use of cannabis on thyroid hormonal levels, cardiovascular indicators, and psychotic...

Case Report: Repeated Series of Ketamine Infusions in Patients With Treatment-Resistant Depression: Presentation of Five Cases

Frontiers in Psychiatry December 2, 2021 Maria Gałuszko‐węgielnik, Adam Włodarczyk, Wiesław Jerzy Cubała et al. 5 citations

Purpose: Approximately 30% of patients with major depressive disorder (MDD) are treatment resistant. There is an unquestionable need for new treatment strategies. Subanesthetic doses of intravenous (IV) ketamine have a rapid antidepressant effect in treatment-resistant depression (TRD). This paper describes the efficacy of repeated series of intravenous ketamine infusions as an add-on treatment...

The Readiness of Psychiatrists to Implement Psychedelic-Assisted Psychotherapy

Frontiers in Psychiatry November 26, 2021 Ahmad Rehman, Habib Syed, Kathryn Forcer et al. 40 citations

Introduction: Psychedelic-assisted psychotherapy is a promising approach in psychiatry; evidence is growing and it may not be long before mainstream services are expected to offer it to selected patients. This pilot study examined the attitudes and knowledge of NHS psychiatrists of all levels towards psychedelic-assisted psychotherapy and explored potential barriers and facilitators to its...

Cannabis Use, Schizotypy and Kamin Blocking Performance

Frontiers in Psychiatry November 23, 2021 Christopher Dawes, Andrea Bickerdike, Cian O’Neill et al. 3 citations

Cannabis use has been associated with increased risk for a first episode of psychosis and inappropriate assignment of salience to extraneous stimuli has been proposed as a mechanism underlying this association. Psychosis-prone (especially schizotypal) personality traits are associated with deficits in associative learning tasks that measure salience allocation. The aim of this study was to...

Self-Medication for Chronic Pain Using Classic Psychedelics: A Qualitative Investigation to Inform Future Research

Frontiers in Psychiatry November 12, 2021 Julia Bornemann, James B. Close, Meg J. Spriggs et al. 43 citations

Background: Chronic Pain is among the leading causes of disability worldwide with up to 60% of patients suffering from comorbid depression. Psychedelic-assisted therapy has recently been found effective in treating a host of mental health issues including depression and has historically been found to be useful in treating pain. Reports of self-medication for chronic pain using psychedelic drugs...

Baseline Power of Theta Oscillations Predicts Mystical-Type Experiences Induced by DMT in a Natural Setting

Frontiers in Psychiatry November 5, 2021 Enzo Tagliazucchi, Federico Zamberlán, Federico Cavanna et al. 23 citations

N,N-Dimethyltryptamine (DMT) is a classic psychedelic capable of inducing short-lasting but profound changes in consciousness. As with other psychedelics, the experience induced by DMT strongly depends upon contextual factors, yet the neurobiological determinants of this variability remain unknown. The present study investigated changes in neural oscillations elicited by inhaled DMT, and...

Translating Psychedelic Therapies From Clinical Trials to Community Clinics: Building Bridges and Addressing Potential Challenges Ahead

Frontiers in Psychiatry November 4, 2021 M.l. Williams, Diana Korevaar, Renee Harvey et al. 23 citations

Research exploring the potential of psychedelic-assisted therapies to treat a range of mental illnesses is flourishing, after the problematic sociopolitical history of psychedelics led to the shutdown of clinical research for almost 40 years. Encouraged by positive results, clinicians and patients are now hopeful that further interruptions to research will be avoided, so that the early promise...

Psychedelic Experiences During the Early COVID-19 Pandemic: Findings From an International Online Survey

Frontiers in Psychiatry November 4, 2021 Ricarda Evens, Simon Reiche, Roman M. Marek et al. 16 citations

Introduction: The current corona virus disease (COVID-19) pandemic has caused a serious global health crisis that has affected large parts of the public and private life worldwide, including the use of psychoactive substances. In this study, we investigated the effect of the COVID-19 pandemic on the use of serotonergic psychedelics, i.e., the settings in which people use psychedelics, the...

Study Protocol for “Psilocybin as a Treatment for Anorexia Nervosa: A Pilot Study”

Frontiers in Psychiatry October 20, 2021 Meg J. Spriggs, Hannah Douglass, Rebecca J. Park et al. 78 citations

Background: Anorexia nervosa (AN) is a serious and life-threatening psychiatric condition. With a paucity of approved treatments, there is a desperate need for novel treatment avenues to be explored. Here, we present (1) an overview of the ways through which Public Patient Involvement (PPI) has informed a trial of psilocybin-assisted therapy for AN and (2) a protocol for a pilot study of...

Antianhedonic Effect of Repeated Ketamine Infusions in Patients With Treatment Resistant Depression

Frontiers in Psychiatry October 18, 2021 Alina Wilkowska, Mariusz S. Wiglusz, Maria Gałuszko‐węgielnik et al. 35 citations

Anhedonia constitutes one of the main symptoms of depressive episode. It correlates with suicidality and significantly effects the quality of patient's lives. Available treatments are not sufficient against this group of symptoms. Ketamine is a novel, rapid acting strategy for treatment resistant depression. Here we report the change in symptoms of anhedonia measured by Snaith-Hamilton Pleasure...

Twelve-Week Yoga vs. Aerobic Cycling Initiation in Sedentary Healthy Subjects: A Behavioral and Multiparametric Interventional PET/MR Study

Frontiers in Psychiatry October 18, 2021 June van Aalst, Lise Jennen, Koen Demyttenaere et al. 9 citations

Interventional yoga studies with an active control group remain scarce and are important to clarify the underlying neurobiology. We conducted an interventional study in healthy controls using simultaneous positron emission tomography/magnetic resonance (PET/MR) imaging and psychometric scales. Thirty healthy, female volunteers (28.4 ± 8.4 years) participated and were randomly assigned to a...

Bridging the Gap? Altered Thalamocortical Connectivity in Psychotic and Psychedelic States

Frontiers in Psychiatry October 13, 2021 Mihai Avram, Helena Rogg, Αλεξάνδρα Κορδά et al. 43 citations

Psychiatry has a well-established tradition of comparing drug-induced experiences to psychotic symptoms, based on shared phenomena such as altered perceptions. The present review focuses on experiences induced by classic psychedelics, which are substances capable of eliciting powerful psychoactive effects, characterized by distortions/alterations of several neurocognitive processes (e.g.,...

Clinical Lycanthropy, Neurobiology, Culture: A Systematic Review

Frontiers in Psychiatry October 11, 2021 Sélim Benjamin Guessoum, Laelia Benoit, Sevan Minassian et al. 15 citations

Background: Culture can affect psychiatric disorders. Clinical Lycanthropy is a rare syndrome, described since Antiquity, within which the patient has the delusional belief of turning into a wolf. Little is known on its clinical or therapeutic correlates. Methods: We conducted a systematic review (PRISMA) on PubMed and Google Scholar, until January 2021. Case reports, data on neurobiological...