A chief aim of the neuroscience of consciousness is to derive how states of conscious experience (i.e., qualia) are related to supporting brain states (e.g., patterns of neural activation within patterns of neural connectivity). This aim goes beyond identifying neuronal correlates of consciousness (NCC) on the one side, and beyond structural descriptions of conscious experience (e.g., qualia...
Floatation-REST (Reduced Environmental Stimulation Therapy) systematically alters sensory and bodily input by combining neutral buoyancy, thermal and proprioceptive neutrality, attenuation of exteroceptive stimulation, and enhancement of cardiorespiratory signaling to the brain. Here we examined whether this non-pharmacological sensory perturbation induces altered states of consciousness and...
Background: Mindfulness research has drawn extensively on the construct's long textual record for conceptual definitions but rarely treated that record as a source of empirical evidence. As a result, contemporary work captures cross-sectional variation across present-day populations without addressing the longer historical trajectories that produced it, leaving open questions about how cultural...
Consciousness science is fragmented, and empirical investigations are confined within each theory of consciousness’ (TOC) framework. Proliferating ToCs accumulate anomalies without progress, operating orthogonally. The principle of recurrency – functional and architectural – offers a unifying, mechanistic scaffold for consciousness to arise. We show that all theories tacitly invoke feedback...
While meditation has been increasingly associated with challenging and adverse experiences, especially in more advanced and high-density practices, little is known about how advanced practitioners experience, make sense of, and integrate non-ordinary experiences that may disrupt their sense of self, reality, embodiment, and meaning. Building on recent advances in the scientific study of...
Abstract Understanding how the sense of self can be attenuated or reconfigured without loss of consciousness remains a central challenge in contemporary consciousness science. We propose a multidimensional framework of graded self-attenuation, in which the self is conceptualized as a dynamic configuration of distributed neural processes. Within this framework, contemplative practice attenuates...
Encounters with apparently autonomous and intelligent non-human entities are a striking and recurrent feature of high-dose N,N-dimethyltryptamine (DMT) experi-ences. Such encounters are typically interpreted as complex hallucinations derived from internally generated brain activity, although many features of the DMT state remain a challenge to explain within the standard neuroscientific...
Understanding affective valence is essential to the fostering of well-being since positive and negative experiences shape our quality of life. One promising approach is to use computational frameworks of perception and action, which seek to formalise the mechanisms underlying valenced experience. Within one such framework, active inference, valence is canonically treated as a consequence of...
How should we understand the radical changes in bodily awareness that occur during advanced meditation? Existing approaches subsume these changes under frameworks of self-dissolution or operationalize them through interoceptive measures that assume ongoing bodily sensation. This paper argues for bracketing the self when studying bodily awareness in advanced concentrative absorption meditation...
Background and objective: Anxiety disorders are among the most prevalent psychiatric disorders worldwide and affect all age groups. Current pharmacological treatments, such as selective serotonergic reuptake inhibitors (SSRI’s) and benzodiazepines, have limitations in terms of adverse effects and efficacy, which highlights the need for alternative therapies. Serotonergic psychedelics have...
Any system that persists must minimise surprisal, thereby gathering evidence for its own generative model, a process known as self-evidencing. However, one dimension of self-evidencing is provably impossible: evidencing the boundary that would constitute the agent as an entity separate from their environment. Recent results in quantum information theory demonstrate that no finite system can...
A central obstacle to a science of qualia is not only that qualia are subjective, but that we lacka principled way to individuate them. Before asking which neural mechanisms generate qualia,we must ask what counts as one quale rather than a compound of several experientialelements. Here we propose that qualia, in the narrow sense, should be defined asindecomposable units of phenomenal...
Mindfulness research faces two recurring methodological problems: near-universal reliance on weak control conditions that cannot isolate specific mechanisms from expectancy effects, and systematic exclusion of low-socioeconomic status (SES) populations through design assumptions that presuppose high literacy, quiet private spaces, and contemplative familiarity. We present the Standardized...
PsyArXivMay 14, 2026Jacob Cohen, Peter Parbo, Per Trads Ørskov et al.
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Background: Social anxiety disorder is a chronic and disabling condition with limited response to standard therapies. Low-dose psilocybin may enhance the effectiveness of exposure-based treatments by modulating neural circuits associated with fear and avoidance. Virtual reality exposure therapy offers a controlled and individualized platform for intervention. Objective: This phase 2b,...
Background: Spiritual and psychotic experiences share overlapping phenomenology, often making clinical differentiation challenging. The growing use of advanced meditation and psychedelics has further blurred this boundary. Methods: A retrospective case series was conducted at the Department of Integrative Medicine,of a tertiary care mental health facility in India. Four individuals presenting...
Recent years have witnessed an “interactive turn” in the cognitive sciences, increasingly foregrounding real-time social interaction and organism–environment dynamics. Yet, even the interactive turn often stops short of its own implications, leaving an individual-first explanatory order largely intact. Taking these implications seriously points toward an explanatory reversal: human...
PsyArXivApril 24, 2026Pedro E Maldonado, Rubén Moreno Bote
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Consciousness is primarily understood as a personal, subjective experience that can co-occur with various other subjective states, such as visual perception, emotions, memories, and awareness of actions. Many of these experiences are linked to the activation of well-defined neuronal processes, with their anatomical substrates often clearly identified. In this paper, we propose that...
We aim to investigate the spatial experience of patients with chronic scotomas caused by lesion to early visual cortex, including primary visual cortex (V1) and adjacent extrastriate visual areas. These experiments are conducted as part of an adversarial collaboration testing contrasting theories of consciousness: Integrated Information Theory (IIT) and two Predictive Processing accounts,...
Debates about artificial consciousness are often framed in terms of verdicts: whether a given system is or is not conscious, and which criteria or theories can deliver such judgments. This paper argues that this framing obscures a more fundamental epistemic challenge.Consciousness science has largely been developed within a narrow population – humans – under background assumptions that support...
This paper develops a phenomenology-first approach to artificial consciousness by reframing consciousness as the subjective experience enacted through an agent’s interface with the world. We shift the methodological focus to first-person structures, modeled mathematically by categories derived from Q-networks to capture actions and phenomenological invariants. In this framework, Q-networks are...
PsyArXivApril 10, 2026George Fejer, Till Holzapfel, Anestis Lalidis Mateo et al.
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Breath-based interactions in virtual reality typically map breathing onto discrete visual objects or downstream physiological proxies. Viscereality takes a different approach, mapping lung volume onto a surrounding space composed of particles arranged in an orb enclosing the participant through interoceptive-exteroceptive sensory substitution, such that inhalation expands the environment...
A central challenge in neuroscience is to establish meaningful links between subjective experience and brain activity. Neurofeedback of meditation states has been proposed as a way to address this challenge by creating a real-time loop between neural signals and first-person experience. Here, the introspective and self-regulation capacities of experienced meditators are harnessed to dynamically...
For ages, scientists have viewed consciousness as some sort of magic trick that suddenly appears when brains achieve a certain level of complexity. What if, however, consciousness has existed all along, even at the smallest levels? Here, I am suggesting a different take: what if consciousness started down at the very subatomic level, and indeed, it was present at the earliest moment? Initially,...
Despite being induced by a transient pharmacological exposure, psychedelic experiences can catalyze enduring psychological transformation, presenting a central challenge for understanding the mechanism of action of psychedelic medicines. To address this challenge, the Allostatic Reset Model (ARM) of psychedelic action is proposed, which conceptualizes psychedelic therapeutic effects as a...
Background: Psilocybin-assisted therapy (PAT) has shown promise for alcohol use disorder (AUD) in randomized controlled trials (RCTs). However, the effects of open-label administration following blinded treatment are unclear. Here, we present safety and efficacy data from an open-label extension of a Phase II RCT (NCT02061293) examining PAT for AUD. Methods: Adults with AUD (N = 59) received a...