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Mystical Experiences, Psychosis, and Psychedelics: A Case Series on Meditation and Psychedelic-Induced Altered States

PsyArXiv May 4, 2026 preprint DOI: 10.31234/osf.io/n63ae_v1 (opens in new tab)

Summary

AI-generated from the abstract

This case series explores the relationship between mystical experiences, psychosis, and psychedelics by examining instances where meditation and psychedelic use induced altered states. The authors present several cases illustrating how such experiences can be difficult to distinguish from psychotic episodes, particularly when they involve shared features like ego dissolution, altered perception, and intense emotions. They argue that while these states may appear similar, they differ in context, meaning, and outcome, with mystical experiences often being integrated positively, whereas psychosis tends to be distressing and disorganizing. The paper highlights the importance of careful assessment and context in differentiating these phenomena.

Study at a glance

Characteristics Case series Case report
Key finding Mystical experiences induced by meditation or psychedelics can resemble psychosis but are typically context-dependent and integrated positively, unlike psychotic episodes.

Abstract

Mystical Experiences, Psychosis, and Psychedelics: A Case Series on Meditation and Psychedelic-Induced Altered States

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