Complexity, commonly defined as the coexistence of integration and differentiation, is a fundamental property of thalamocortical networks and is regarded as a prerequisite for adaptive brain function and consciousness. A variety of metrics have been developed to estimate neural complexity from recorded activity and are increasingly employed in both research and clinical settings. Yet, the...
bioRxiv Preprint ServerDecember 9, 2025Tomas Berjaga-Buisan, Juan Manuel Monti, Martina Cortada et al.
preprint
The quest for reliable and objective measures of consciousness is critical in basic and clinical neuroscience. Across species, the Perturbational Complexity Index (PCI) has emerged as a robust empirical marker by directly perturbing the brain, yet its underlying principles of physics are not fully understood. Here, we bridge this gap by introducing a non-invasive framework based on generative...