Psycho-oncology
September 11, 2019
Linda Cillessen, M. Johannsen, A. Speckens et al.
326 citations
Mindfulness-based interventions reduce psychological distress in cancer patients and survivors, according to a systematic review and meta-analysis of randomized controlled trials. Since 2012, the number of published trials has more than doubled, allowing for a more robust analysis. The review examined the efficacy of these interventions on psychological distress as the primary outcome, along with other health outcomes. The findings support the use of mindfulness-based approaches in psycho-oncology to improve mental health among individuals affected by cancer.
Brain and Behavior
May 24, 2023
Hannah Ellerbroek, I. Hanssen, Karen Lathouwers et al.
Mindfulness-based cognitive therapy (MBCT) appears feasible for patients with both chronic noncancer pain and opioid use disorder (OUD), though data are limited. This qualitative study explored the process of change during MBCT in this specific population. Participants reported that the intervention helped them relate differently to pain and cravings, suggesting MBCT may be a promising treatment for this dual-diagnosis group.
Journal of Affective Disorders
May 1, 2023
M. Cladder-Micus, J. Vrijsen, A. Fest et al.
For chronically depressed patients who have not responded to prior treatments, mindfulness-based cognitive therapy (MBCT) produces clinical benefits that persist for at least six months after the program ends. Depressive symptoms, quality of life, rumination, mindfulness skills, and self-compassion all remained stable during follow-up, and remission rates actually increased further. Patients who entered treatment with higher levels of rumination showed greater reductions in depressive symptoms and better quality of life at six months, after accounting for initial symptom severity. Other factors—duration of the current depressive episode, degree of treatment resistance, childhood trauma, and baseline mindfulness or self-compassion—did not predict outcomes.
Cognition & Emotion
December 22, 2021
T. D. Stalmeier, Jelle Lubbers, M. Cladder-Micus et al.
Negative self-referential processing is well-studied in unipolar depression but less in bipolar disorder (BD). In 49 patients with BD from a randomized trial of mindfulness-based cognitive therapy (MBCT), those receiving MBCT plus treatment as usual (TAU, n=23) showed a reduction in negative self-referential memory bias over time compared with TAU alone (n=26). At baseline, all three measures of self-referential processing—positive and negative attributions and negative memory bias—were linked to depressive symptoms. The findings are preliminary and suggest that reducing negative self-referential memory bias may help prevent and treat depressive symptoms in BD through MBCT.
Depression and Anxiety
November 9, 2021
J. D. de Klerk-Sluis, M. Huijbers, S. Löcke et al.
Mindfulness-based cognitive therapy (MBCT) helps prevent relapse in major depressive disorder by reducing cognitive reactivity and rumination while increasing self-compassion and mindfulness. The authors note that while rumination and mindfulness after MBCT are linked to relapse, no prior research has examined whether these factors—along with cognitive reactivity and self-compassion—are associated with relapse before MBCT begins. This gap suggests that pre-treatment psychological characteristics may influence treatment outcomes, but the study does not report any new empirical data.
Journal of Attention Disorders
January 6, 2020
D. Geurts, M. Schellekens, L. Janssen et al.
Mindfulness-based cognitive therapy (MBCT) plus treatment as usual, compared to treatment as usual alone, improved positive mental health in adults with ADHD at 6-month follow-up through increased self-compassion, but reductions in ADHD symptoms were not mediated by mindfulness skills or self-compassion. Additional analyses suggested that improvements in self-reported inhibition mediated the reduction in ADHD symptoms. The effect of MBCT on ADHD symptoms and positive mental health thus occurred via different mechanisms.
Depression and Anxiety
August 8, 2018
M. Cladder-Micus, A. Speckens, J. Vrijsen et al.
Mindfulness-based cognitive therapy (MBCT) is effective for patients with remitted or currently active depression, but its effectiveness for those with chronic, treatment-resistant depression has not yet been established.
Journal of Clinical Oncology
June 28, 2018
F. Compen, E. Bisseling, M. Schellekens et al.
Mindfulness-based cognitive therapy (MBCT) and an individual internet-based version (eMBCT) both reduced psychological distress in cancer patients more than treatment as usual (TAU). In a randomized trial of 245 distressed cancer patients, those receiving MBCT or eMBCT reported significantly less distress post-intervention (Cohen's d = .45 and .71, respectively). Both interventions also reduced fear of cancer recurrence and rumination, and improved mental health-related quality of life, mindfulness skills, and positive mental health compared to TAU. Physical health-related quality of life did not improve. Post-treatment psychiatric diagnosis prevalence was lower with MBCT (33% improvement) and eMBCT (29% improvement) versus TAU (16%), but these differences were not statistically significant.
Mindfulness
January 12, 2017
M. Huijbers, R. Crane, W. Kuyken et al.
In a multi-centre trial of mindfulness-based cognitive therapy (MBCT) for recurrent depression, teacher competence—assessed using the Mindfulness-Based Interventions: Teaching Assessment Criteria (MBI:TAC)—showed no significant association with patient adherence, potential mechanisms of change (rumination, cognitive reactivity, mindfulness, self-compassion), or key outcomes (depressive symptoms post-treatment and depressive relapse/recurrence over 15 months). The authors suggest several possible explanations, including the standardized delivery of MBCT, the emphasis on self-reliance in the learning process, participant-related factors, challenges in assessing teacher competence, and the limited sample of videotaped sessions. Further research is needed to explore these explanations.
BMC Psychiatry
November 9, 2015
M. Cladder-Micus, J. Vrijsen, E. Becker et al.
A randomized controlled trial will compare Mindfulness-Based Cognitive Therapy (MBCT) plus treatment-as-usual (TAU) against TAU alone for patients with chronic, treatment-resistant depression who have already received antidepressant medication and either cognitive behavioral therapy or interpersonal therapy. The primary outcome is depressive symptoms; secondary outcomes include remission rates, quality of life, rumination, mindfulness skills, and self-compassion. Assessments occur at baseline and after the intervention or TAU period, with follow-up at three and six months post-MBCT for completers. The trial aims to provide information on MBCT's effectiveness in this population.