Consciousness is hypothesized to emerge from a sophisticated balance between functional integration and segregation across large-scale brain networks. However, how these topological properties are disrupted in disorders of consciousness (DoC), and whether they can predict long-term recovery, remain to be established. Using resting-state functional MRI and graph-theoretical modeling in patients...
Disorders of Consciousness (DOC) are characterized by abnormal function or disrupted connectivity of consciousness-related neural circuits, mainly presenting as Vegetative State/Unresponsive Wakefulness Syndrome (VS/UWS) and Minimally Conscious State (MCS), which impose a heavy burden on patients' families and society. Non-Invasive Brain Stimulation (NIBS) has emerged as a core research...
Ketamine and electroconvulsive therapy (ECT) achieve rapid remission in treatment-resistant depression. However, their mechanisms of action—the understanding of which is essential for refining therapeutic precision—remain unclear1, 2–3. Here, using mouse models, we identify adenosine signalling as a central pathway that underlies the antidepressant effects of these interventions. Results from...
This study aimed to investigate the brain's hemodynamic responses (HRO) and functional connectivity in patients with disorders of consciousness (DoC) in response to acute pressure pain stimulation using near-infrared spectroscopy (NIRS). Patients diagnosed with DoC underwent pressure stimulation while brain activity was measured using NIRS. Changes in oxygenated hemoglobin (HbO) and...
To identify the independent risk factors for postpartum depression in elderly primiparas and to evaluate the effects of mindfulness-based psychological intervention. A retrospective analysis was conducted on 75 women with postpartum depression who received treatment at the First Hospital of Nanchang from January 2021 to March 2022. Among them, 33 women who received routine psychological health...
Objective To study the role of L-arginine/nitric oxide (NO) pathway in the antidepressant effects of ketamine. Methods Forty two male Wistar rats (200-250 g) were equally randomized into 7 groups (n=6): control group (C group), L-Arginine (a precursor of NO) group (LA group), L-NAME(an non-selectivity inhibitor of NO synthase) group (LN group), ketamine 3 mg/kg group (K3 group), ketamine 10...