Depression and Anxiety
April 17, 2013
Anthony P. King, Thane M. Erickson, Nicholas D. Giardino et al.
258 citations
Group mindfulness-based cognitive therapy (MBCT) adapted for combat posttraumatic stress disorder (PTSD) is feasible, acceptable, and associated with clinically meaningful reductions in PTSD symptom severity, particularly avoidance and numbing symptoms, and trauma-related cognitions such as self-blame. In an outpatient VA clinic, veterans with chronic PTSD who completed an 8-week MBCT group showed significant improvement on clinician-rated PTSD symptoms, whereas those in brief treatment-as-usual did not. Homework compliance was good, and drop-out rates were modest. The findings suggest MBCT as a brief adjunctive therapy for combat PTSD, but randomized controlled trials are needed to confirm efficacy.
Biological psychiatry. Cognitive neuroscience and neuroimaging
April 1, 2025
Saampras Ganesan, Fernando A Barrios, Ishaan Batta et al.
6 citations
Meditation practices, which have shown therapeutic benefits for conditions like depression, pain, addiction, and anxiety, have been studied with neuroimaging over the past decade. However, existing neuroscientific models are based on small, heterogeneous datasets, limiting generalizability and replicability. The ENIGMA-Meditation consortium is the first worldwide collaborative effort to conduct systematic meta- and mega-analyses of globally distributed neuroimaging data using standardized methods. This framework aims to improve statistical power and address multidomain heterogeneity in meditation practice types, experience, and experimental design. The consortium will generate rigorous neuroscientific insights into the mechanisms underlying meditation's therapeutic effects on psychological and cognitive attributes.
April 8, 2024
Saampras Ganesan, Aki Tsuchiyagaito, Greg J Siegle et al.
2 citations
preprint
Meditation practices, which have been adapted into manualized interventions for conditions like depression, pain, addiction, and anxiety, show therapeutic promise, but their neuroscientific basis remains unclear. Current neuroimaging studies rely on small, heterogeneous datasets that vary in practice types, participant experience, clinical targets, and imaging methods, limiting generalizability and replicability. To address this, the ENIGMA-Meditation consortium was formed as a global collaboration to conduct systematic meta- and mega-analyses of distributed neuroimaging data using standardized methods. This framework aims to improve statistical power and rigorously characterize the neural mechanisms underlying meditation's effects on psychological and cognitive attributes, advancing the field of contemplative neuroscience.
Depression and Anxiety
April 1, 2016
Anthony P. King, Stefanie R Block, Rebecca K Sripada et al.
Mindfulness training may help treat PTSD by strengthening connections between brain networks involved in self-focused thought and executive control. In combat veterans with PTSD, a mindfulness-based group therapy reduced symptoms (effect size d = 0.92), though not significantly more than an active control therapy (d = 0.46). Brain scans showed that mindfulness training increased resting-state functional connectivity between the default mode network and regions supporting attention and control, such as the dorsolateral prefrontal cortex and dorsal anterior cingulate cortex. This increased connectivity correlated with improvements in avoidance and hyperarousal symptoms, suggesting a neural mechanism for how mindfulness helps regulate attention and reduce PTSD symptoms.