The International Journal of Neuropsychopharmacology
August 11, 2025
Gihyun Yoon, Brian Pittman, E. Ralevski et al.
IMPORTANCE The comorbidity of major depressive disorder (MDD) and alcohol use disorder (AUD) is often treated inadequately. This study evaluated the impact of adding the opioid receptor blocker, naltrexone, to the NMDA glutamate receptor antagonist, ketamine, for the treatment of MDD comorbid with AUD. In so doing, it also attempted to shed light on the contribution of opioid receptor...
Current Psychiatry Reports
August 26, 2017
J. Krystal, Chadi G. Abdallah, Lynnette A. Averill et al.
Purpose of ReviewStudies of the neurobiology and treatment of PTSD have highlighted many aspects of the pathophysiology of this disorder that might be relevant to treatment. The purpose of this review is to highlight the potential clinical importance of an often-neglected consequence of stress models in animals that may be relevant to PTSD: the stress-related loss of synaptic...
Molecular Psychiatry
April 11, 2017
Irina Esterlis, Nicole DellaGioia, Robert H Pietrzak et al.
The mechanisms of action of the rapid antidepressant effects of ketamine, an N-methyl-D-aspartate glutamate receptor antagonist, have not been fully elucidated. This study examined the effects of ketamine on ligand binding to a metabotropic glutamatergic receptor (mGluR5) in individuals with major depressive disorder (MDD) and healthy controls. Thirteen healthy and 13 MDD nonsmokers...
Psychiatry Research
January 12, 2011
Gerald W Valentine, G. Mason, R. Gomez et al.
The NMDA receptor antagonist ketamine can induce a rapid improvement in depressive symptoms that often endures for days after a single intravenous dose. The pharmacodynamic basis for this effect is poorly understood. Using a proton magnetic resonance spectroscopy ([1H]-MRS) method that previously detected a normalization of amino acid neurotransmitter (AANt) content after chronic treatment with...
Biological Psychiatry
April 10, 2010
Philip R. Corlett, D. D’Souza, J. Krystal
We would like to report a case of Capgras syndrome in a healthy subject, which was induced by ketamine, [an antagonist of the N-methyl D-aspartate (NMDA) subtype of glutamate receptors]. We believe this is the first report of delusion-like misidentification following controlled administration of a psychotomimetic drug, raising the possibility that the neurochemical and cognitive mechanisms...
Biological Psychiatry
January 15, 2000
J. Krystal, A. Bennett, D. Abi‐Saab et al.
BACKGROUND The demands of the Wisconsin Card Sorting Test (WCST) change with experience. This report contains two studies designed to examine N-methyl-D-aspartate (NMDA) receptor contributions to the executive components of WCST performance. These aspects of WCST performance figure more prominently in the initial completion of this task than in subsequent task repetitions in healthy...