Lawrence S. Kegeles

2 papers in the library · 59 citations · publishing 2000-2020

Papers

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Assessment of Relationship of Ketamine Dose With Magnetic Resonance Spectroscopy of Glx and GABA Responses in Adults With Major Depression

JAMA Network Open August 12, 2020 Matthew S. Milak, Rain Rashid, Zhengchao Dong et al. 59 citations

Importance: A single subanesthetic dose of ketamine produces an antidepressant response in patients with major depressive disorder (MDD) within hours, but the mechanism of antidepressant effect is uncertain. Objective: To evaluate whether ketamine dose and brain glutamate and glutamine (Glx) and γ-aminobutyric acid (GABA) level responses to ketamine are related to antidepressant benefit and...

DOI: 10.1001/jamanetworkopen.2020.13211 Full text Ketamine Depression economics Magnetic resonance imaging Nuclear magnetic resonance +2

Modulation of amphetamine-induced striatal dopamine release by ketamine in humans: implications for schizophrenia.

Biological Psychiatry October 1, 2000 Lawrence S. Kegeles, Anissa Abi‐dargham, Y. Zea‐Ponce et al.

BACKGROUND Recent brain imaging studies have indicated that schizophrenia is associated with increased amphetamine-induced dopamine release in the striatum. It has long been hypothesized that dysregulation of subcortical dopamine systems in schizophrenia might result from a failure of the prefrontal cortex (PFC) to adequately control subcortical dopaminergic function. The activity of midbrain...

DOI: 10.1016/s0006-3223(00)00976-8 Full text