15 papers in the library · 647 citations · publishing 2006-2026
Fortschr Neurol Psychiatr June 8, 2026 Udo Bonnet, Norbert Scherbaum, Georg Juckel et al.
[Intravenous Subnarcotic Ketamine Infusions for Treatment-Resistant Depression: Historical Development, Comparison with Esketamine Nasalspray, and Prospects].
Brain Sciences April 22, 2025 Fabrizio Schifano, Stefania Bonaccorso, Davide Arillotta et al. 14 citations
Background: "Chemsex" involves the intake of a range of drugs (e.g., synthetic cathinones, gamma-hydroxybutyric acid/gamma-butyrolactone (GHB/GBL), ketamine, methamphetamine, "poppers", type V phosphodiesterase (PDE) inhibitors, MDMA/ecstasy, cocaine, cannabis, and occasionally a few other molecules as well, to enhance and prolong sexual experiences. This paper aims to provide an overview of...
Expert Review of Clinical Pharmacology November 2, 2023 Fabrizio Schifano, Alessandro Vento, Norbert Scherbaum et al. 30 citations
Clinicians should be regularly informed about the range of NPS and their medical, psychobiological and psychopathological risks both in the acute and long term. Future research should focus on an integrative model in which pro-drug websites' analyses are combined with advanced research approaches, including computational chemistry studies so that in vitro and in vivo preclinical studies of...
Frontiers in Psychiatry 2022 Udo Bonnet, Michael Specka, Ann-Kristin Kanti et al. 4 citations
There is a lack of benefit/harm assessments of illicit and licit psychoactive substances performed by substance-dependent users in comparison to addiction medicine experts. We extended the analyses of substance harm/benefit assessments of German addiction medicine experts (N = 101), in parts reported recently in this journal [doi.org/10.3389/fpsyt.2020.59219], by the perspectives of...
Suchttherapie August 1, 2021 Norbert Scherbaum
Abb. 1 zeigt die Strukturformel des Salvinorins A (Hauptwirkstoff) sowie die Anwendungsarten und die handelsüblichen Formen von Salvia divinorum.
Experimental Neurology May 1, 2021 Fabrizio Schifano, Stefania Chiappini, Andrea Miuli et al. 49 citations
The use of several new psychoactive substances (NPS) has become very popular and is posing global health risks. Chemically and pharmacologically diverse molecules are constantly emerging and are presenting with a wide range of clinical implications. Serotonin toxicity, and specifically Serotonin Syndrome (SS), might develop as a result of an over-activation of the serotoninergic system caused...
Frontiers in Psychiatry July 7, 2020 Michael Specka, Thomas Kuhlmann, Jürgen Sawazki et al. 42 citations
Background About 15 years ago, a diverse group of new recreational psychotropic substances began to emerge, which were marketed for example as “legal highs,” “research chemicals,” or “designer drugs.” These substances were later subsumed under the label “Novel Psychoactive Substances” (NPS). Important NPS classes are cathinones, synthetic cannabimimetics, phenethylamines, and herbal drugs. The...
Psychopharmacology May 1, 2020 Toby Lea, Nicole Amada, Henrik Jungaberle et al.
The regular consumption of very small doses of psychedelic drugs (known as microdosing) has been a source of growing media and community attention in recent years. However, there is currently limited clinical and social research evidence on the potential role of microdosing as therapies for mental and substance use disorders. This paper examined subjective experiences of microdosing...
Psychological Medicine July 22, 2019 Fabrizio Schifano, Flavia Napoletano, Stefania Chiappini et al. 118 citations
BACKGROUND: The present paper provides an updated review of both the large number of new/novel/emerging psychoactive substances (NPS) and their associated psychopathological consequences. Focus was here given on identification of those NPS being commented in specialised online sources and the related short-/long-term psychopathological and medical ill-health effects. METHODS: NPS have been...
Pharmacopsychiatry April 25, 2017 Norbert Scherbaum, Fabrizio Schifano, Udo Bonnet 46 citations
Over the last few years, hundreds of new psychoactive substances (NPS) have been identified in Europe. Apart from some herbal compounds, NPS mainly include synthetic cannabinoids and a range of new synthetic stimulants (e. g., cathinones). Synthetic NPS are often developed whilst modifying the basic chemical (e. g., phenethylamine or tryptamine) structure. Although the pharmacology and...
Human Psychopharmacology Clinical and Experimental March 1, 2012 Ornella Corazza, Fabrizio Schifano, Pierluigi Simonato et al. 157 citations
On the basis of the material available both in the scientific literature and on the web, this paper aims to provide a pharmacological, chemical and behavioural overview of the novel compound methoxetamine. This is a dissociative drug related to ketamine, with a much longer duration of action and intensity of effects. A critical discussion of the availability of information on the web of...
Current Clinical Pharmacology May 1, 2011 Ornella Corazza, Fabrizio Schifano, Magı́ Farré et al. 98 citations
Based on the material available in both the scientific literature and on the web, the present paper provides an updated pharmacological, chemical, toxicological and behavioural overview of Bromo-Dragonfly (1-(8-bromobenzo[1,2-b;4,5-b']difuran-4-yl)-2-aminopropane; 'B-fly'). B-Fly is a powerful, long lasting, LSD-like, hallucinogenic drug, which has been associated with a number of acute...
Psychopharmacology April 2011 Fabrizio Schifano, Antonio Albanese, Suzanne Fergus et al.
Recently, those substances deriving from the active ingredient of the Khat plant, cathinone, have been rising in popularity. Indeed, 4-methylmethcathinone (mephedrone; 'meow meow' and others) has been seen by some as a cheaper alternative to other classified recreational drugs. We aimed here at providing a state-of-the-art review on mephedrone history and prevalence of misuse, chemistry,...
International Journal of Culture and Mental Health December 1, 2009 Fabrizio Schifano, Ornella Corazza, Paolo Deluca et al. 79 citations
The aim of the study was to foster the collection and analysis of data from web pages related to information on the consumption, manufacture and sale of Spice products, a brand name for an herbal smoking blend, sold as legal substitute for cannabis. The Google search engine was used to carry out an 8-language qualitative assessment of information available on Spice products in a sample of about...
Gesundheitswesen (Bundesverband der Arzte des Offentlichen Gesundheitsdienstes (Germany)) May 1, 2006 Holger Siemann, Michael Specka, Fabrizio Schifano et al. 10 citations
The German pages of the Internet were searched for the presence of the hallucinogenic herbal drug Salvia divinorum, which is not dealt with in current addiction medicine or psychiatric text books. The investigation is part of the EU sponsored project "Psychonaut" as preparatory work for the development of an Internet-based early warning system. The first 100 websites of the search using "Salvia...