Nature Mental Health
May 1, 2026
Daniel Bello, Sophia H. Blyth, Rachel A Rabin et al.
Cannabis and tobacco use are highly prevalent among people with psychosis and are associated with medical comorbidities and poor prognosis. Concurrent use of cannabis and tobacco (‘co-use’) is rising in the general population, but has not been studied in psychosis. Given the devastating consequences of cannabis and tobacco use, it is critical to understand how their co-use affects psychiatric...
JAMA Psychiatry
April 9, 2025
Jessica Ahrens, Sabrina D. Ford, Betsy Schaefer et al.
This cohort study investigates the association between cannabis and the midbrain dopamine pathway involved in psychosis.
EClinicalMedicine
September 8, 2023
Mathilde Argote, Guillaume Sescousse, Jérôme Brunelin et al.
31 citations
Background: The association between cannabis use and positive symptoms in schizophrenia spectrum disorders is well documented, especially via meta-analyses. Yet, findings are inconsistent regarding negative symptoms, while other dimensions such as disorganization, depression, and excitement, have not been investigated. In addition, meta-analyses use aggregated data discarding important...
Neuropsychopharmacology
October 2017
Rachel A Rabin, Mera S Barr, Michelle S Goodman et al.
Cross-sectional studies of the effects of cannabis on cognition in schizophrenia have produced mixed results. Heavy and persistent cannabis use in schizophrenia is a common clinical problem, and effects of controlled abstinence from cannabis in these patients have not been carefully evaluated. The present study sought to determine the effects of cannabis abstinence on cognition in patients with...
Jessica Ahrens, Sabrina D. Ford, Betsy Schaefer et al.
preprint
Abstract Importance Despite evidence that individuals who use cannabis early in life are at elevated risk of psychosis and that the neurotransmitter dopamine has a role in both conditions, the mechanism linking the two conditions remains unclear. Objective To use neuromelanin-sensitive MRI (neuromelanin-MRI), a practical, proxy measure of dopamine function, to assess whether a common alteration...