The effects of d-lysergic acid diethylamide (LSD), 2,5-dimethoxy-4-methylamphetamine (DOM) and d-amphetamine on operant responding in control and 6-hydroxydopamine-treated rats.
Randall L. Commissaris, William H. Lyness, J J Cordon, K E Moore, Richard H. Rech
Pharmacology, Biochemistry, and Behavior November 1980 DOI: 10.1016/0091-3057(80)90002-7 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental animal study Peer reviewed |
|---|---|
| Population | Food-deprived male rats |
| Interventions | LSD DOM d-amphetamine |
| Dose | 6-OHDA 200 micrograms/10 microliter X 2 |
| Topics | LSD |
| Key findings | LSD and DOM produced dose-dependent pauses in fixed-ratio responding followed by recovery, while d-amphetamine slowed and disrupted responding without pausing. Destroying central catecholamine neurons with 6-OHDA (reducing catecholamines to under 25 percent of control without affecting serotonin) left LSD and DOM effects unchanged but significantly diminished the d-amphetamine effect, suggesting the drugs differ in how much they depend on catecholamines. |
Abstract
The purpose of the present study was to determine the role of central catecholaminergic neuronal systems in the effects of LSD, DOM and d-amphetamine on fixed ratio (FR) operant responding in rats. Food-deprived male rats were trained to press a bar for food reinforcement on a FR-40 schedule. Control responding on this schedule is characterized by a rapid, constant rate of responding (approximately 100 responses/min) throughout a 40 min test session. LSD and DOM, as with other hallucinogens, produced dose-dependent periods of nonresponding or "pausing," followed by reinstatement of responding at or near the control rate. Administration of the non-hallucinogen, d-amphetamine, did not produce "pausing," but caused the response rate to slow and become erratic. In animals pretreated intraventricularly with 6-hydroxydopamine (6-OHDA; 200 micrograms/10 microliter X 2), the response to LSD and DOM was unchanged, while the response to d-amphetamine was significantly diminished. The neurotoxin significantly decreased brain catecholamines to less than 25 percent of control in al regions examined, without altering 5-HT concentrations in these same regions. These data demonstrate that the effects of LSD and DOM on FR-40 responding are quite different from those of d-amphetamine, and that this difference may be due to the extent of catecholamine involvement in the effects of these agents.
Comparable studies
Other preclinical and animal studies on LSD, most cited first.
Citations in the library
Cited by 8
- Animal Models of Serotonergic Psychedelics ACS Chemical Neuroscience September 24, 2012
- The effects of d-lysergic acid diethylamide (LSD), 2,5-dimethoxy-4-methylamphetamine (DOM), pentobarbital and methaqualone on punished responding in control and 5,7-dihydroxytryptamine-treated rats Pharmacology, Biochemistry, and Behavior May 1, 1981
- The 5HT2 antagonist pirenperone reverses disruption of FR-40 by hallucinogenic drugs. Pharmacology, Biochemistry, and Behavior May 1985
- Naloxone alters the effects of LSD, DOM and quipazine on operant behavior of rats. Pharmacology, Biochemistry, and Behavior September 1984
- Neurotransmitter basis of the behavioral effects of hallucinogens. Neuroscience & Biobehavioral Reviews 1982
and 3 more in the library
Cites 3
- Behavioral sensitivity to LSD: Dependency upon the pattern of central 5HT depletion Pharmacology, Biochemistry, and Behavior May 1, 1977
- Enhancement of the behavioral effects of 2,5-dimethoxy-4-methyl-amphetamine (DOM) by pretreatment with p-chlorophenylalanine. Pharmacology, Biochemistry, and Behavior October 1980
- Comparative effects of hallucinogenic drugs on rotational behavior in rats with unilateral 6-hydroxydopamine lesions. European Journal of Pharmacology July 15, 1977