Enhancement of the behavioral effects of 2,5-dimethoxy-4-methyl-amphetamine (DOM) by pretreatment with p-chlorophenylalanine.
Randall L. Commissaris, William H. Lyness, K E Moore, Richard H. Rech
Pharmacology, Biochemistry, and Behavior October 1980 DOI: 10.1016/0091-3057(80)90290-7 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Preclinical animal study Peer reviewed |
|---|---|
| Sample size | 7 |
| Population | Food-deprived male rats |
| Interventions | 2 5-dimethoxy-4-methyl amphetamine (DOM) p-chlorophenylalanine (PCPA) |
| Dose | 0.5 mg/kg DOM; 100 mg/kg PCPA |
| Duration | 40-min test sessions; PCPA administered on three successive days |
| Key points | DOM at 0.5 mg/kg suppressed bar-pressing for food on an FR-40 schedule, and pretreatment with PCPA (which reduced brain 5-HT to 15-26% of control) produced greater nonresponding after DOM. The authors suggest that disruption of 5-HT neuronal activity enhances the effects of the phenethylamine hallucinogen DOM. |
Abstract
Seven food deprived male rats were trained to press a bar on a fixed ratio-40 (FR-40) schedule of food reinforcement. Administration of 0.5 mg/kg 2,5-dimethoxy-4-methyl amphetamine (DOM) immediately before the start of the session resulted in cessation of responding for some portion of the 40-min test session. Three successive days of p-chlorophenylalanine (PCPA) administration (100 mg/kg) 30 min after each session reduced 5-hydroxytryptamine (5-HT) to 15-26% of control concentrations in various brain regions but did not alter control rates of responding under the FR-40 schedule. Administration of 0.5 mg/kg DOM following this PCPA pretreatment resulted in a greater amount of nonresponding than observed earlier. These data suggest that the effects of the phenethylamine hallucinogen DOM are enhanced by disruption of 5-HT neuronal activity.
Citations in the library
Cited by 7
- Methylenedioxyamphetamine (MDA) and methylenedioxymethamphetamine (MDMA) cause selective ablation of serotonergic axon terminals in forebrain: immunocytochemical evidence for neurotoxicity Journal of Neuroscience August 1, 1988
- Animal Models of Serotonergic Psychedelics ACS Chemical Neuroscience September 24, 2012
- Mescaline: excitatory effects on acoustic startle are blocked by serotonin2 antagonists Psychopharmacology November 1, 1987
- Naloxone alters the effects of LSD, DOM and quipazine on operant behavior of rats. Pharmacology, Biochemistry, and Behavior September 1984
- Neurotransmitter basis of the behavioral effects of hallucinogens. Neuroscience & Biobehavioral Reviews 1982
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