DISAGGREGATION OF BRAIN POLYSOMES AFTER ADMINISTRATION OF d‐LYSERGIC ACID DIETHYLAMIDE (LSD) IN VIVO
Journal of Neurochemistry July 1, 1976 L. Holbrook, Ian R. Brown 42 citations
Abstract— Polysomes from three major brain regions of the young rabbit were disaggregated after in vivo administration of d ‐LSD. The effect was transient and demonstrated maximal shift after 30–60 min with a return to normal levels by 4 h. Brain polysome disaggregation was elicited by LSD dosages of either 10 or 100/μg/kg body wt. The polysome shift was not caused by RNase degradation and...