Gisela Grecksch

2 papers in the library · 71 citations · publishing 2014-2015

Papers

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Tolerance to LSD and DOB induced shaking behaviour: differential adaptations of frontocortical 5-HT(2A) and glutamate receptor binding sites.

Behavioural Brain Research March 15, 2015 Tobias Buchborn, Helmut Schröder, Daniela C. Dieterich et al.

Serotonergic hallucinogens, such as lysergic acid diethylamide (LSD) and dimethoxy-bromoamphetamine (DOB), provoke stereotype-like shaking behaviour in rodents, which is hypothesised to engage frontocortical glutamate receptor activation secondary to serotonin2A (5-HT2A) related glutamate release. Challenging this hypothesis, we here investigate whether tolerance to LSD and DOB correlates with...

DOI: 10.1016/j.bbr.2014.12.014 Full text 5-ht2a receptor Lysergic acid diethylamide Mglu2/3 glutamate receptor Frontal cortex +3

Repeated lysergic acid diethylamide in an animal model of depression: Normalisation of learning behaviour and hippocampal serotonin 5-HT2 signalling

Journal of Psychopharmacology April 30, 2014 Tobias Buchborn, H. Schröder, V. Höllt et al. 71 citations

A re-balance of postsynaptic serotonin (5-HT) receptor signalling, with an increase in 5-HT1A and a decrease in 5-HT2A signalling, is a final common pathway multiple antidepressants share. Given that the 5-HT1A/2A agonist lysergic acid diethylamide (LSD), when repeatedly applied, selectively downregulates 5-HT2A, but not 5-HT1A receptors, one might expect LSD to similarly re-balance the...

DOI: 10.1177/0269881114531666