This paperback publication has 428 pages of text, an additional 131 pages of references and an 18-page subject index. The text is organized in 10 chapters, each liberally endowed with relevant figures and tables. The first 3 chapters (72 pages) are very useful because they contain numerous definitions and introduce the reader to neuroscientific and pharmacological topics that appear throughout...
The synthesis of four possible in vitro metabolites of the hallucinogen 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane (DOM) is described. These compounds, 1-(2,5-dimethoxy-4-methylphenyl(-2-propanone, the corresponding oxime, 1-(2,5-dimethoxy-4-methylphenyl)-2-propanol, and 1-(2,5-dimethoxy)-4-methylphenyl-2-(hydroxylamino)propane, could be products of side chain metabolic oxidation of DOM.
The synthesis of 2-amino-4,7-dimethoxy-5-methylindane (12a), the cyclic analog of the known hallucinogen 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane (DOM), is described. The key intermediate was trans-2-amino-4,7-dimethoxy-6-methyl-1-indanol (trans-10a) which was converted to 12a in two ways. The prolonged action of hydrochloric acid on trans-10a gave 4,7-dimethoxy-5-methyl-2-indanone...
The synthesis of a series of 4-substituted 1-(2,5-dimethoxyphenyl)-2-aminopropanes, in which the 4-substituent is Br, Cl, I, NO2, NH2, and NHAc, is described. These compounds are analogs of 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane (DOM), a known hallucinogen. A synthesis of N-(2,5-dimethoxy-4-methylphenethyl)hydroxylamine, the N-hydroxy homolog of DOM, is also reported. Brief reference...