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The potency of hallucinogenic amphetamine derivatives of the 1-(2,5-dimethoxy-4-alkylphenyl)-2-aminopropane type drops dramatically when the length of the 4-alkyl substituent exceeds propyl or when the substituent is branched. This investigation was directed toward evaluating changes in behavioral and biochemical pharmacology resulting from introducing chirality into the 4-alkyl group of such...
AbstractDie aus den Dihydrobenzofuranen (I) zugänglichen Aldehyde (II) werden durch Kondensation mit Nitroethan und anschließende Reduktion in die Aminopropyl‐Derivate (V) übergeführt, die auf LSD‐analoge Wirkung bei Ratten geprüft werden.