The Synthesis of Some Analogs of the Hallucinogen 1-(2,5-Dimethoxy-4-methylphenyl)-2-aminopropane (DOM)
Ronald T. Coutts, Jerry L. Malicky
Canadian Journal of Chemistry May 1, 1973 DOI: 10.1139/v73-210 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Peer reviewed |
|---|---|
| Key points | Reports synthetic routes to six 4-substituted DOM analogs (4-Br, 4-Cl, 4-I, 4-NO2, 4-NH2, 4-NHAc) and to N-(2,5-dimethoxy-4-methylphenethyl)hydroxylamine, the N-hydroxy homolog of DOM. Pharmacology is mentioned only briefly, with no results given. |
Abstract
The synthesis of a series of 4-substituted 1-(2,5-dimethoxyphenyl)-2-aminopropanes, in which the 4-substituent is Br, Cl, I, NO2, NH2, and NHAc, is described. These compounds are analogs of 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane (DOM), a known hallucinogen. A synthesis of N-(2,5-dimethoxy-4-methylphenethyl)hydroxylamine, the N-hydroxy homolog of DOM, is also reported. Brief reference is made to the preliminary pharmacology of these compounds.
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