5 papers in the library · publishing 1973-1974
Chemischer Informationsdienst April 30, 1974 Ronald T. Coutts, Jerry L. Malicky
AbstractFür physiologische Untersuchungen werden die mit dem Metaboliten DOM (VII) verwandten Produkte (V) und (VIII) synthetisiert.
Canadian Journal of Chemistry February 1, 1974 Ronald T. Coutts, Jerry L. Malicky
The synthesis of four possible in vitro metabolites of the hallucinogen 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane (DOM) is described. These compounds, 1-(2,5-dimethoxy-4-methylphenyl(-2-propanone, the corresponding oxime, 1-(2,5-dimethoxy-4-methylphenyl)-2-propanol, and 1-(2,5-dimethoxy)-4-methylphenyl-2-(hydroxylamino)propane, could be products of side chain metabolic oxidation of DOM.
Canadian Journal of Chemistry February 1, 1974 Ronald T. Coutts, Jerry L. Malicky
The synthesis of 2-amino-4,7-dimethoxy-5-methylindane (12a), the cyclic analog of the known hallucinogen 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane (DOM), is described. The key intermediate was trans-2-amino-4,7-dimethoxy-6-methyl-1-indanol (trans-10a) which was converted to 12a in two ways. The prolonged action of hydrochloric acid on trans-10a gave 4,7-dimethoxy-5-methyl-2-indanone...
Chemischer Informationsdienst July 10, 1973 Ronald T. Coutts, Jerry L. Malicky
AbstractDie Darstellungen einer Reihe von Analogen von DOM (Ia) werden beschrieben.
Canadian Journal of Chemistry May 1, 1973 Ronald T. Coutts, Jerry L. Malicky
The synthesis of a series of 4-substituted 1-(2,5-dimethoxyphenyl)-2-aminopropanes, in which the 4-substituent is Br, Cl, I, NO2, NH2, and NHAc, is described. These compounds are analogs of 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane (DOM), a known hallucinogen. A synthesis of N-(2,5-dimethoxy-4-methylphenethyl)hydroxylamine, the N-hydroxy homolog of DOM, is also reported. Brief reference...