medRxivOctober 19, 2026Joel Gelernter, Jack Hirsch, Cassie M. Overstreet et al.
preprint
Frequent nightmares affect roughly 2-6% of the population and may reflect underlying psychopathology, such as post-traumatic stress disorder (PTSD), or, when recurrent and distressing, be diagnosed as nightmare disorder (ND). The genetic basis of nightmares remains poorly understood. We performed a genome-wide association study (GWAS) meta-analysis of nightmare frequency (NF) across 207,243...
The phase 2 data presented here support the development of TSND-201 for posttraumatic stress disorder (PTSD), a disorder for which there is a significant unmet need for rapid-acting and effective treatments. TSND-201 (methylone) is a highly selective, rapid-acting neuroplastogen that releases serotonin, norepinephrine, and dopamine without direct activity at 5-hydroxytryptamine (5-HT) 2A...
Abstract Floatation‐Reduced Environmental Stimulation Therapy (REST) is a procedure that reduces stimulation of the human nervous system by minimizing sensory signals from visual, auditory, olfactory, gustatory, thermal, tactile, vestibular, gravitational, and proprioceptive channels, in addition to minimizing musculoskeletal movement and speech. Initial research has found that Floatation‐REST...
The psychological process of individuation as experienced in Jungian work may lead to states of consciousness that resemble advanced spiritual developments across religious traditions and cultures. This is where Westerners may reach a common ground with the East. In the essentials and with respect to the final goal there is little difference among the many ways to the self, even if the cultural...