Trends in Cognitive Sciences
April 22, 2016
Tim Bayne, Jakob Hohwy, Adrian M. Owen
443 citations
The notion of a level of consciousness is a key construct in the science of consciousness. Not only is the term employed to describe the global states of consciousness that are associated with post-comatose disorders, epileptic absence seizures, anaesthesia, and sleep, it plays an increasingly influential role in theoretical and methodological contexts. However, it is far from clear what...
PLoS Computational Biology
October 16, 2014
Srivas Chennu, Paola Finoia, Evelyn Kamau et al.
249 citations
Theoretical advances in the science of consciousness have proposed that it is concomitant with balanced cortical integration and differentiation, enabled by efficient networks of information transfer across multiple scales. Here, we apply graph theory to compare key signatures of such networks in high-density electroencephalographic data from 32 patients with chronic disorders of consciousness,...
Proceedings of the National Academy of Sciences
September 15, 2014
Lorina Naci, Rhodri Cusack, Mimma Anello et al.
239 citations
The interpretation of human consciousness from brain activity, without recourse to speech or action, is one of the most provoking and challenging frontiers of modern neuroscience. We asked whether there is a common neural code that underpins similar conscious experiences, which could be used to decode these experiences in the absence of behavior. To this end, we used richly evocative...
Science
March 2, 2007
Adrian M. Owen, Martin R. Coleman, Melanie Boly et al.
72 citations
Additional data, supported by relevant functional neuroimaging literature, confirm that the “normal” patterns of brain activity reported in a patient who was clinically diagnosed as vegetative could not have occurred “automatically” in the absence of conscious awareness. The most parsimonious explanation remains that this patient was consciously aware despite her diagnosis of vegetative state.
Science
September 7, 2006
Adrian M. Owen, Martin R. Coleman, Melanie Boly et al.
1,974 citations
We used functional magnetic resonance imaging to demonstrate preserved conscious awareness in a patient fulfilling the criteria for a diagnosis of vegetative state. When asked to imagine playing tennis or moving around her home, the patient activated predicted cortical areas in a manner indistinguishable from that of healthy volunteers.
Dian Lu, Adapa Ram, Robin Carhart-Harris et al.
Abstract Large-scale functional connectivity (FC) networks are typically treated as discrete neuroanatomical entities, yet their organisation in regions where multiple systems converge remains poorly understood. Here we investigate the posterior precuneus (PCu)—a key hub of the default mode network (DMN) situated at the interface with the frontoparietal control network (FPCN)—using a...