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Annual Review of Neuroscience

ISSN 1545-4126

6 papers in the library · 4,747 citations · publishing 1986-2026

Papers

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The Emerging Neurobiology of Psychedelics: Critical Periods, Metaplasticity, and Extracellular Matrix Remodeling.

Annual Review of Neuroscience July 1, 2026 Gül Dölen, Makenzie L Wilkinson

Psychedelics are a broad category of compounds that induce altered states of consciousness. These drugs have shown remarkable promise for the treatment of debilitating disorders ranging from posttraumatic stress disorder to depression and addiction. Although early studies focused on linking binding targets of psychedelics to their therapeutic effects, these pharmacological and biochemical...

Anesthetics as Treatments for Depression: Clinical Insights and Underlying Mechanisms.

Annual Review of Neuroscience February 19, 2025 Macauley Smith Breault, Sirma Orguc, Ohyoon Kwon et al. 13 citations

Major depressive disorder and treatment-resistant depression are significant worldwide health problems that need new therapies. The success of the anesthetic ketamine as an antidepressant is well known. It is less widely known that several other anesthetic agents have also shown antidepressant effects. These include nitrous oxide, propofol, isoflurane, sevoflurane, dexmedetomidine, and xenon....

DOI: 10.1146/annurev-neuro-112723-062031 (opens in new tab) Full text (opens in new tab) Depression treatment Anesthesia research Mental health breakthroughs Drug repurposing

The Brain's Default Mode Network

Annual Review of Neuroscience May 4, 2015 Marcus E. Raichle 4,082 citations

The brain's default mode network consists of discrete, bilateral and symmetrical cortical areas, in the medial and lateral parietal, medial prefrontal, and medial and lateral temporal cortices of the human, nonhuman primate, cat, and rodent brains. Its discovery was an unexpected consequence of brain-imaging studies first performed with positron emission tomography in which various novel,...