Neuroimage
October 22, 2018
Hong Gu, Yuzheng Hu, Xi Chen et al.
Deactivation of the default mode network (DMN) is one of the most reliable observations from neuroimaging and has significant implications in development, aging, and various neuropsychiatric disorders. However, the neural mechanism underlying DMN deactivation remains elusive. As the coordination of regional neurochemical substrates and interregional neural interactions are both essential in...
American Journal of Psychiatry
April 2014
Christopher D. Verrico, Hong Gu, Melanie L Peterson et al.
Epidemiological findings suggest that, relative to adults, adolescents are more vulnerable to the adverse persistent effects of cannabis on working memory. However, the potential confounds inherent in human studies preclude direct determination of a cause-and-effect relationship between adolescent cannabis use and heightened susceptibility to persistent working memory impairments. Consequently,...
Neuropsychopharmacology
May 2012
Christopher D. Verrico, Shijing Liu, Elizabeth J Bitler et al.
Among adolescents, the perception that cannabis can cause harm has decreased and use has increased. However, in rodents, cannabinoid administration during adolescence induces working memory (WM) deficits that are more severe than if the same exposure occurs during adulthood. As both object and spatial WM mature in a protracted manner, although apparently along different trajectories, adolescent...
Proceedings of the National Academy of Sciences
February 21, 2012
Hanbing Lu, Qihong Zou, Hong Gu et al.
627 citations
The default mode network (DMN) in humans has been suggested to support a variety of cognitive functions and has been implicated in an array of neuropsychological disorders. However, its function(s) remains poorly understood. We show that rats possess a DMN that is broadly similar to the DMNs of nonhuman primates and humans. Our data suggest that, despite the distinct evolutionary paths between...