Amyloid Plaques Disrupt Resting State Default Mode Network Connectivity in Cognitively Normal Elderly
Yvette I. Sheline, Marcus E. Raichle, Abraham Z. Snyder, John C. Morris, Denise Head, Suzhi Wang, Mark A. Mintun
Biological Psychiatry October 15, 2009 DOI: 10.1016/j.biopsych.2009.08.024 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Observational cohort Peer reviewed |
|---|---|
| Sample size | 103 |
| Population | Cognitively normal participants and Alzheimer's disease patients |
| Topics | Default mode network |
| Citations | 608 |
| Key findings | Cognitively normal participants with brain amyloid deposition showed altered resting-state functional connectivity in the same regions and direction as Alzheimer's disease patients. |
Abstract
BackgroundImportant functional connections within the default mode network (DMN) are disrupted in Alzheimer's disease (AD), likely from amyloid-beta (Abeta) plaque-associated neuronal toxicity. Here, we sought to determine if pathological effects of Abeta amyloid plaques could be seen, even in the absence of a task, by examining functional connectivity in cognitively normal participants with and without preclinical amyloid deposition.MethodsParticipants with Alzheimer's disease (AD) (n = 35) were compared with 68 cognitively normal participants who were further subdivided by positron emission tomography (PET) Pittsburgh Compound-B (PIB) imaging into those without evidence of brain amyloid (PIB-) and those with brain amyloid (PIB+) deposition.ResultsResting state functional magnetic resonance imaging (fMRI) demonstrated that, compared with the PIB- group, the PIB+ group differed significantly in functional connectivity of the precuneus to hippocampus, parahippocampus, anterior cingulate, dorsal cingulate, gyrus rectus, superior precuneus, and visual cortex. These differences were in the same regions and in the same direction as differences found in the AD group.ConclusionsThus, before any manifestations of cognitive or behavioral changes, there were differences in resting state connectivity in cognitively normal subjects with brain amyloid deposition, suggesting that early manifestation of Abeta toxicity can be detected using resting state fMRI.
Comparable studies
Other observational and cohort studies on default mode network, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| A default mode of brain function Normal adult human brain | 2001 | Observational study | |
| Resting-State Functional Connectivity Reflects Structural Connectivity in the Default Mode Network Healthy subjects | 2008 | Observational cohort | |
| Meditation experience is associated with increased cortical thickness Participants with extensive Insight meditation experience and matched controls | 2005 | Observational cohort | n = 20 |
| Meditation experience is associated with differences in default mode network activity and connectivity Experienced meditators and matched meditation-naive controls | 2011 | Observational cohort | |
| The precuneus/posterior cingulate cortex plays a pivotal role in the default mode network: Evidence from a partial correlation network analysis Healthy subjects | 2008 | Observational study |
Citations in the library
Cited by 9
- Relationships between Beta-Amyloid and Functional Connectivity in Different Components of the Default Mode Network in Aging Cerebral Cortex March 7, 2011
- Default mode network connectivity in stable vs progressive mild cognitive impairment Neurology January 13, 2011
- Missing piece of the puzzle in the science of consciousness: Resting state and endogenous correlates of consciousness Consciousness and Cognition February 2, 2017
- Amyloid-driven disruption of default mode network connectivity in cognitively healthy individuals Brain Communications 2021
- The Longitudinal Trajectory of Default Mode Network Connectivity in Healthy Older Adults Varies As a Function of Age and Is Associated with Changes in Episodic Memory and Processing Speed Journal of Neuroscience February 13, 2018
and 4 more in the library