Rat brains also have a default mode network
Hanbing Lu, Qihong Zou, Hong Gu, Marcus E. Raichle, Elliot A. Stein, Yihong Yang
Proceedings of the National Academy of Sciences February 21, 2012 DOI: 10.1073/pnas.1200506109 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Observational study Peer reviewed |
|---|---|
| Population | Rats |
| Topics | Default mode network |
| Citations | 627 |
| Key findings | Rats possess a default mode network broadly similar to that of nonhuman primates and humans, suggesting the DMN is a fundamental mammalian brain feature that integrates multimodal sensory and affective information to guide behavior. |
Abstract
The default mode network (DMN) in humans has been suggested to support a variety of cognitive functions and has been implicated in an array of neuropsychological disorders. However, its function(s) remains poorly understood. We show that rats possess a DMN that is broadly similar to the DMNs of nonhuman primates and humans. Our data suggest that, despite the distinct evolutionary paths between rodent and primate brain, a well-organized, intrinsically coherent DMN appears to be a fundamental feature in the mammalian brain whose primary functions might be to integrate multimodal sensory and affective information to guide behavior in anticipation of changing environmental contingencies.
Comparable studies
Other preclinical and animal studies on default mode network, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Large-scale topology and the default mode network in the mouse connectome Mouse brain | 2014 | Observational study | |
| Hippocampal Sharp-Wave Ripples Influence Selective Activation of the Default Mode Network Anesthetized monkeys | 2016 | Observational study | |
| Psilocybin-induced default mode network hypoconnectivity is blunted in alcohol-dependent rats Healthy rats and a rat model of alcohol relapse | 2023 | Randomized, placebo-controlled crossover pharmaco-fMRI study | |
| Altered functional connectivity within the default mode network in two animal models with opposing episodic memories Rats (control, LPS-challenged, and footshock-exposed groups) | 2018 | Animal model study | |
| Psilocybin triggers an activity-dependent rewiring of large-scale cortical networks Mice | 2025 | Experimental study in mice |
Citations in the library
Cited by 43
- The Brain's Default Mode Network Annual Review of Neuroscience May 4, 2015
- Large-scale topology and the default mode network in the mouse connectome Proceedings of the National Academy of Sciences December 15, 2014
- Psychedelics, but Not Ketamine, Produce Persistent Antidepressant-like Effects in a Rodent Experimental System for the Study of Depression ACS Chemical Neuroscience March 5, 2020
- Shaped by the Past: The Default Mode Network Supports Cognition that Is Independent of Immediate Perceptual Input PLoS One June 30, 2015
- Superior pattern processing is the essence of the evolved human brain Frontiers in Neuroscience August 22, 2014
and 38 more in the library
Cites 4
- A default mode of brain function Proceedings of the National Academy of Sciences January 16, 2001
- Decoupling of the brain's default mode network during deep sleep Proceedings of the National Academy of Sciences June 19, 2009
- Consciousness and Anesthesia Science November 7, 2008
- Functional connectivity in the resting brain: A network analysis of the default mode hypothesis Proceedings of the National Academy of Sciences December 27, 2002