Background: Psychedelics, including classic psychedelics, 3,4-methylenedioxymethamphetamine (MDMA), and ketamine, are increasingly investigated for psychiatric disorders, but their effects on sleep remain unclear. Objectives: To systematically evaluate the effects of these interventions on subjective and objective sleep outcomes and summarize sleep-related adverse events. Design: A systematic...
Abstract: Objectives: Diabetic peripheral neuropathy (DPN) is a common chronic complication of diabetes, with neuropathic pain and sensory abnormalities severely affecting patients’ quality of life. Current pharmacological treatments have limitations including insufficient efficacy and adverse reactions. Mindfulness-based interventions (MBIs) show potential in chronic pain management, yet their...
MoleculesFebruary 22, 2024Hanbo Yao, Xiaodong Wang, Jiaxin Chi et al.9 citations
Major Depressive Disorder (MDD) is a complex mental disorder that involves alterations in signal transmission across multiple scales and structural abnormalities. The development of effective antidepressants (ADs) has been hindered by the dominance of monoamine hypothesis, resulting in slow progress. Traditional ADs have undesirable traits like delayed onset of action, limited efficacy, and...